Results 61 to 70 of about 359,174 (252)

Prolonged survival of a female patient with total pelvic exenteration [PDF]

Vojnosanitetski Pregled, 2005
Background. To present a female patient who lived 5 years after total pelvic exenteration (TPE). Case report. The female patient underwent TPE due to retrovesicovaginal fistula as a consequence of locoregional irradiation after the operation for the ...
Ignjatović Dragan, Jevtić Miodrag, Mirković Darko   +2 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Advances in Diagnostic, Prognostic and Predictive Biomarker Testing for the Characterization of Uterine Mesenchymal Neoplasms

Onco
The family of uterine mesenchymal neoplasms is diverse in etiology and clinical impact. While histomorphology remains central to diagnostic classification, numerous biomarkers have been developed to aid in refining diagnoses and informing optimal ...
Julia Dedda, Roman E. Zyla
doaj   +1 more source

Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5-year results [PDF]

, 2011
Objective: To compare the long-term results of uterine artery embolisation (UAE) with surgery for women with symptomatic uterine fibroids. Design Pragmatic, open, multicentre, randomised trial. Setting Twenty-seven participating UK secondary care centres.
MA Lumsden, Wu, O., O Wu, LE Craig, Khaund, A., Lumsden, M.A., Moss, J.G., Cooper, K.G., A Khaund, KG Cooper, JG Moss, Murray, G.D., Craig, L.E., Murray, L., LS Murray, GD Murray   +15 more
core   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

The "Other" Uterine Mesenchymal Neoplasms: Recent Developments and Emerging Entities.

Uterine mesenchymal neoplasms are a challenging group of tumors that often show overlapping morphologic features and immunohistochemical profiles.
Pinto, Andre, Bennett, Jennifer A
core   +1 more source

The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids [PDF]

, 2010
Objective The aim of this study was to evaluate and compare both ovarian function and menstrual characteristics following uterine artery embolisation (UAE) and surgery. Design Subgroup of women from a randomised controlled trial.
D. Lyons, Murray, G. D., S. Rashid, Cooper, K., Rashid, S., Khaund, A., Lumsden, M.A., Moss, J.G., Murray, L.S., Lumsden, M. A., Moss, J. G., J. G. Moss, M. A. Lumsden, Lyons, D., K. Cooper, Murray, G.D., A. Khaund, Murray, L., L. S. Murray, G. D. Murray   +19 more
core   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

MED12 Mutations are Present in The Majority of Uterine Leiomyomas

, 2011
Major finding: MED12 is mutated in 70% of uterine leiomyomas (fibroids). Impact: The Mediator kinase module is implicated in the genesis of multiple types of neoplasms.

core   +1 more source

Conservative Treatment of Ewing’s Sarcoma of the Uterus in Young Women

Case Reports in Obstetrics and Gynecology, 2015
Ewing sarcoma-primitive neuroectodermal tumors (ES/PNETs) constitute a family of neoplasms characterized by a continuum of neuroectodermal differentiations. ES/PNET of the uterus is rare.
Giuseppe Loverro, Leonardo Resta, Edoardo Di Naro, Anna Maria Caringella, Salvatore Andrea Mastrolia, Mario Vicino, Massimo Tartagni, Luca Maria Schonauer   +7 more
doaj   +1 more source