Results 171 to 180 of about 1,617,640 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Health-related quality of life changes in patients with Q-fever fatigue syndrome: a four-year follow-up study, 10 years post-infection. [PDF]

Qual Life Res
Stemerdink NC, Heemskerk SCM, Hartman E, Wesseling M, Tieleman P, Burdorf A, Haagsma JA.   +6 more
europepmc   +1 more source

Other title: Senate Bill 384 - Testimony on Behalf of the Citizens' Utility Ratepayer Board by Steve Rarrick, Staff Attorney

, 2010
application/pdf; "February 1-2, 2010."; Testimony before the Kansas Legislature, Senate Utility Committee, presented by Steve Rarrick, Staff Attorney, Citizens' Utility Ratepayer Board.Testimony in opposition to Senate Bill 384.
Rarrick, Steve (Craig Steven).
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Preference-based scoring algorithm to estimate societal utilities based on the patient-reported experience of cognitive impairment in schizophrenia (PRECIS) instrument. [PDF]

Qual Life Res
Hoogendoorn M, Santi I, Sussex AK, Aggio D, Wang J, Lloyd A.   +5 more
europepmc   +1 more source

Other title: House Bill 2240 - Testimony on Behalf of the Citizens' Utility Ratepayer Board by David Springe, Consumer Counsel

, 2005
application/pdf; "February 9, 2005."; Testimony before the Kansas Legislature, House Utilities Committee, presented by David Springe, Consumer Counsel, Citizens' Utility Ratepayer Board.Testimony in opposition to House Bill 2240.
Springe, David.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Choice and impact of EQ-5D-5L value set in cost-utility analyses alongside multinational trials: Insights from PREFERABLE-EFFECT and CONVINCE. [PDF]

PLoS One
Schouten AEM, Frederix GWJ, Stuiver MM, Fischer F, Hiensch AE, Cromm K, Canaud B, Strippoli GFM, May AM, van der Meulen MP, PREFERABLE-EFFECT Scientific Committee, and the CONVINCE Scientific Committee.   +11 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Study of the Characteristics of Two Immobilized Microbial Materials in Degradation and Evolution of Petroleum Hydrocarbon

ACS Omega, 2020
Xiaofang Luo, Lihua Chen, Shujing Zhao, Zhongchun Lei, Miaomiao Xia, Chuantao Zhang   +5 more
doaj   +1 more source