Results 71 to 80 of about 1,190,848 (267)

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Somatic embryogenesis and genetic transformation in peony: challenges and applications

Frontiers in Plant Science
Paeonia, a traditional ornamental flower and economically important crop, requires efficient propagation and targeted breeding for sustainable industrial application. Somatic embryogenesis provides a potentially transformative method for regenerating and
Linlan Fu, Linlan Fu, Yongliang Wang, Yongliang Wang, Jiawei Jiang, Jiawei Jiang, Zhihong Zhang, Zhihong Zhang   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Intention to Use ChatGPT in Office Work in Romania: Between Utility and Hedonic Motivation [PDF]

Amfiteatru Economic
In the short evolution from 2019 to the present, the application domains of ChatGPT have experienced exponential growth, ranging from editing, consulting, banking, healthcare, journalism, and mass media to entertainment, education, and remote technical
Mirela Cătălina Türkeș, Aurelia-Felicia Stăncioiu , Cristian-Silviu Bănacu   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Utilization Phase: Utilization of OUSAF

, 2018
To demonstrate the utilization of the OUSAF, in this chapter, a methodological approach is adopted which provides a systematic flow of activities and the interaction between different components to analyse the utilization. This methodological approach is presented in Sect. 8.2.
Ashraf, J, Hussain, OK, Hussain, FK, Chang, EJ   +3 more
openaire   +2 more sources

John Henry Newman’s Idea of a University as Critique of Jeremy Bentham’s Utilitarian Conception of Education

Theology and Philosophy of Education, 2023
The main thesis of this article is that Newman’s famous Idea of a University cannot be fully appreciated without the background of the educational programmes popularized in the first half of the 19th century, which have their matrix in the utilitarian ...
Andrej Mária Čaja
doaj   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source