Results 41 to 50 of about 675 (148)
Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening [PDF]
, 2019 Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide.
Eadsforth, Thomas C. +7 more
core +3 more sources
Journal of Biological Chemistry, 2005 l-Rhamnose is an essential component of the cell wall and plays roles in mediating virulence and adhesion to host tissues in many microorganisms. Glucose-1-phosphate thymidylyltransferase (RmlA, EC 2.7.7.24) catalyzes the first reaction of the four-step ...
Zilian Zhang +5 more
semanticscholar +1 more source
Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival [PDF]
, 2012 The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is largely responsible for alterations in cell metabolism in hypoxic tumor cells.
Bellot, Grégory +5 more
core +4 more sources
Insights into the binding specificity and catalytic mechanism ofN-acetylhexosamine 1-phosphate kinases through multiple reaction complexes [PDF]
, 2015 Utilization of N-acetylhexosamine in bifidobacteria requires the specific lacto-N-biose/galacto-N-biose pathway, a pathway differing from the Leloir pathway while establishing symbiosis between humans and bifidobacteria.
Chang, Chin-Yuan +5 more
core +1 more source
Planta, 2009 Analyses of transgenic sugarcane clones with 45–95% reduced cytosolic pyrophosphate: d-fructose-6-phosphate 1-phosphotransferase (PFP, EC 2.7.1.90) activity displayed no visual phenotypical change, but significant changes were evident in in vivo ...
Margaretha J. van der Merwe +4 more
semanticscholar +1 more source
Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes [PDF]
, 2019 In Trypanosoma cruzi, the causal agent of Chagas disease, the first seven steps of glycolysis are compartmentalized in glycosomes, which are authentic but specialized peroxisomes.
Acosta, Héctor +8 more
core +2 more sources
A collection of enhancer trap insertional mutants for functional genomics in tomato
Plant Biotechnology Journal, 2017 Summary With the completion of genome sequencing projects, the next challenge is to close the gap between gene annotation and gene functional assignment.
F. Pérez-Martín +21 more
semanticscholar +1 more source
Scientific Reports, 2017 The emergence of antibiotic-resistant pathogenic bacteria is a healthcare problem worldwide. We evaluated the antimicrobial activity of rhodomyrtone, an acylphloroglucinol present in Rhodomyrtus tomentosa leaves, against the human Gram-positive pathogen ...
W. Mitsuwan +7 more
semanticscholar +1 more source
UDP-Sugar Producing Pyrophosphorylases: Distinct and Essential Enzymes With Overlapping Substrate Specificities, Providing de novo Precursors for Glycosylation Reactions [PDF]
, 2019 Nucleotide sugars are the key precursors for all glycosylation reactions and are required both for oligo- and polysaccharides synthesis and protein and lipid glycosylation.
Daniel Decker, Leszek A. Kleczkowski
core +1 more source
Applied Microbiology and BiotechnologyGrifola frodosa polysaccharides, especially β-D-glucans, possess significant anti-tumor, antioxidant and immunostimulatory activities. However, the synthesis mechanism remains to be elucidated.
Jian Li +9 more
semanticscholar +1 more source