Results 71 to 80 of about 469,896 (294)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis   +5 more
wiley   +1 more source

BOOK REVIEW: Beuk Paul L. Th. (ed.): Checklist of the Diptera of the Netherlands.

open access: yesEuropean Journal of Entomology, 2003
KNNV Uitgeverij, Utrecht 2002, 448 pp.
J. OLEJNÍČEK
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay   +5 more
wiley   +1 more source

Civil Society Iraq: Ethnic, Religious, and Location Influences on Outgroup Perception [PDF]

open access: yes, 2004
Civil Society Iraq: Ethnic, Religious, and Location Influences on Outgroup Perception Jon Gresham* April 2004 A significant research question in the immediate post-war (May 2003) environment of Iraq was: "How do Iraqis’ ethnicity, religious affiliation,
Gresham, Dr. JN
core  

A persona-based modelling for contextual requirements [PDF]

open access: yes, 2018
[Context & Motivation] Personas are a technique used to guide developing products accommodating people diversity. They are archetypes reflecting common combinations of users’ characteristics, needs and goals.
Ali, Raian   +4 more
core   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon   +13 more
wiley   +1 more source

Effects of Stimulus Luminance, Stimulus Color and Intra-Stimulus Color Contrast on Visual Field Mapping in Neurologically Impaired Adults Using Flicker Pupil Perimetry

open access: yesEye and Brain, 2023
Brendan L Portengen,1,2 Giorgio L Porro,1,* Douwe Bergsma,3 Evert J Veldman,4 Saskia M Imhof,1 Marnix Naber2,* 1Department of Ophthalmology, University Medical Center Utrecht, Utrecht, the Netherlands; 2Experimental Psychology, Helmholtz ...
Portengen BL   +5 more
doaj  

Legacy of Le Grand Départ Tour de France Utrecht 2015 [PDF]

open access: yes, 2015
for the Sport Management Australia New Zealand conference in Tasmania in 2015. The aim of the abstract is to describe the research we are carrying out in Utrecht to the legacy of the first two stages of the Tour the France 2015 in the city of Utrecht ...
Dijk, Bake   +3 more
core  

Lifetime of dynamic heterogeneity in strong and fragile kinetically constrained spin models

open access: yes, 2005
Kinetically constrained spin models are schematic coarse-grained models for the glass transition which represent an efficient theoretical tool to study detailed spatio-temporal aspects of dynamic heterogeneity in supercooled liquids.
Ediger M D   +4 more
core   +3 more sources

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel   +12 more
wiley   +1 more source

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