Results 91 to 100 of about 7,107 (213)
The FASEB Journal, Volume 39, Issue 19, 15 October 2025.ERRα promotes muscle regeneration. ERRα drives angiogenic and mitochondrial metabolic gene program in proliferating and differentiating myogenic cells. ERRα also induces myogenic factor genes such as MyoG. Through these pathways ERRα promotes muscle regeneration in the skeletal muscle in acute injury and chronic myopathy.
Thi Thu Hao Nguyen +8 more
wiley +1 more source
Utrophin Transcription Is Activated by an Intronic Enhancer [PDF]
Journal of Biological Chemistry, 2000 The utrophin gene codes for a large cytoskeletal protein closely related to dystrophin. Its transcription is driven by a TATA-less promoter. Here we analyzed 40 kilobases of the 5' end region of the utrophin gene searching for new utrophin regulatory elements in muscle cells.
GALVAGNI F., OLIVIERO, Salvatore
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Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype.
PLoS ONE, 2008 We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response.
Kurt W Prins +2 more
doaj +1 more source
Subcutaneous injection, from birth, of epigallocatechin-3-gallate, a component of green tea, limits the onset of muscular dystrophy in mdx mice: a quantitative histological, immunohistochemical and electrophysiological study [PDF]
, 2018 Dystrophic muscles suffer from enhanced oxidative stress. We have investigated whether administration of an antioxidant, epigallocatechin-3-gallate (EGCG), a component of green tea, reduces their oxidative stress and pathophysiology in mdx mice, a mild ...
Goto, Junpei +6 more
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FEBS Letters, Volume 599, Issue 20, Page 2878-2895, October 2025.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Utrophin: A Structural and Functional Comparison to Dystrophin
Brain Pathology, 1996 Utrophin is an autosomally‐encoded homologue of dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene. Although, Utrophin is very similar in sequence to dystrophin and possesses many of the protein‐binding properties ascribed to dystrophin, both proteins are expressed in an apparently reciprocal manner and may be coordinately ...
D J, Blake, J M, Tinsley, K E, Davies
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Utrophin up-regulation by an artificial transcription factor in transgenic mice.
PLoS ONE, 2007 Duchenne Muscular Dystrophy (DMD) is a severe muscle degenerative disease, due to absence of dystrophin. There is currently no effective treatment for DMD.
Elisabetta Mattei +13 more
doaj +1 more source
Developmental Dynamics, Volume 254, Issue 10, Page 1115-1132, October 2025.Abstract Background The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial surface of the neural plate as internalization begins to form the neural keel in the hindbrain region of the zebrafish embryo.
Claudio Araya +11 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 19, Page 5067-5085, October 2025.Duchenne muscular dystrophy is a severe neuromuscular wasting disease that is caused by a primary defect in dystrophin protein. A targeted mass‐spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy.
Erynn E. Johnson, James M. Ervasti
wiley +1 more source
Dystrophin and utrophin: the missing links!
FEBS Letters, 1995 There is considerable sequence homology between dystrophin and utrophin, both at the protein and DNA level, and consequently it was assumed that their domain structures and functions would be similar. As more of the detailed biochemical and cell biological properties of these two proteins become known, so it becomes clear that there are subtle if not ...
Winder, S.J. +2 more
openaire +2 more sources