Utrophin up-regulation helps maintain normal cardiac geometry in a gene therapy model for Duhenne muscular dystrophy heart disease [abstract] [PDF]
, 2010 Duchenne muscular dystrophy (DMD) is the most common childhood muscle wasting disease. DMD sufferers rarely survive past their mid-twenties succumbing to respiratory or heart failure.
Bostick, Brian P., 1979-
core
Utrophin: A Structural and Functional Comparison to Dystrophin [PDF]
, 1996 Derek J. Blake +2 more
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l-arginine improves dystrophic phenotype in mdx mice
Neurobiology of Disease, 2005 A possible treatment for Duchenne muscular dystrophies would be to compensate for dystrophin loss by increasing the expression of utrophin, another cytoskeletal protein of the muscle membrane. We previously found that l-arginine, the substrate for nitric
Vincent Voisin +7 more
doaj
The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms
BMC Genomics, 2007 Background Dystrophins and dystrobrevins are distantly related proteins with important but poorly understood roles in the function of metazoan muscular and neuronal tissues.
Hughes Simon M +10 more
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Adhesion-dependent tyrosine phosphorylation of β-dystroglycan regulates its interaction with utrophin [PDF]
, 2000 Marian James +6 more
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Regulation and functional significance of utrophin expression at the mammalian neuromuscular synapse [PDF]
, 2000 Anthony O. Gramolini +2 more
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Dystrophin and utrophin influence fiber type composition and post-synaptic membrane structure [PDF]
, 2000 Jill A. Rafael
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Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. [PDF]
, 2019 Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously.
Blondelle, Jordan +13 more
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Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter [PDF]
, 2001 Federico Galvagni +2 more
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iNOS Expression In Dystrophinopathies Can Be Reduced By Somatic Gene Transfer of Dystrophin or Utrophin [PDF]
, 2001 Jean‐Pierre Louboutin +4 more
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