Characterisation of alpha-dystrobrevin in muscle [PDF]
, 1998 Dystrophin-related and associated proteins are important for the formation and maintenance of the mammalian neuromuscular junction. Initial studies in the electric organ of Torpedo californica showed that the dystrophin-related protein dystrobrevin (87K)
Blake, D. J. +4 more
core
Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.EVs were isolated from plasma of ME/CFS patients and healthy controls at baseline, and 15 min and 24 h postexercise. Untargeted proteomics revealed dysregulation in energy metabolism, the complement system, and the endoplasmic reticulum stress response. Changes in EV protein levels postexercise are associated with post‐exertional malaise.
Katherine A. Glass +3 more
wiley +1 more source
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin‐Deficient Hearts
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCardiomyopathy is a leading cause of mortality among Duchenne muscular dystrophy patients and lacks effective therapies. Phosphodiesterase type 5 is implicated in dystrophic pathology, and the phosphodiesterase type 5 inhibitor tadalafil has ...
David W. Hammers +5 more
doaj +1 more source
Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. [PDF]
, 2019 Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously.
Blondelle, Jordan +13 more
core +1 more source
Advanced Science, Volume 12, Issue 16, April 24, 2025.This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du +7 more
wiley +1 more source
High Throughput Screening in Duchenne Muscular Dystrophy: From Drug Discovery to Functional Genomics
Biology, 2014 Centers for the screening of biologically active compounds and genomic libraries are becoming common in the academic setting and have enabled researchers devoted to developing strategies for the treatment of diseases or interested in studying a ...
Thomas J.J. Gintjee +2 more
doaj +1 more source
MicroRNAs modulated by local mIGF-1 expression in mdx dystrophic mice [PDF]
, 2015 Duchenne muscular dystrophy (DMD) is a X-linked genetic disease in which the absence of dystrophin leads to progressive lethal skeletal muscle degeneration.
Coggi, Angela +3 more
core +2 more sources
Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes
Journal of Neurochemistry, Volume 169, Issue 4, April 2025.Glycine receptors (GlyRs) play key roles in brain development, learning/memory, inflammatory pain sensitization, and rhythmic breathing. GlyRs depend upon stable and transient protein–protein interactions that influence synaptic localization, homeostasis, signaling pathways, and receptor function.
Sean D. Fraser +4 more
wiley +1 more source
Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin [PDF]
, 2018 The dystrophin-associated protein complex (DPC) consisting of syntrophin, dystrobrevin, and dystroglycan isoforms is associated either with dystrophin or its homolog utrophin.
Fritschy, Jean-Marc +2 more
core
A novel point mutation affecting Asn76 of dystrophin protein leads to dystrophinopathy [PDF]
, 2017 K
Ajzner, Éva +8 more
core +1 more source