Results 221 to 230 of about 7,799 (249)

Complex transcription of the utrophin gene: A study of short utrophin isoforms

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Regulation of utrophin in transgenic mice.

, 2016
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Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton

Bhat A, Das A, Iyer M, Beri S, Talluri S, Koester D, Rao M, Mayor S.   +7 more
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Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Lippert A, Rochussen A, Kebabci A, Winkel A, Franze K, Fletcher D, Griffiths G.   +6 more
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Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle

The Journal of Gene Medicine, 2008
AbstractBackgroundDuchenne muscular dystrophy is caused by the absence of the muscle cytoskeletal protein dystrophin. Utrophin is an autosomal homologue of dystrophin, and overexpression of utrophin is expected to compensate for the dystrophin deficit.
Jun, Tanihata, Naoki, Suzuki, Yuko, Miyagoe-Suzuki, Kazuhiko, Imaizumi, Shin'ichi, Takeda   +4 more
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A study of short utrophin isoforms in mice deficient for full-length utrophin

Mammalian Genome, 2003
Utrophin can functionally replace dystrophin in dystrophin-deficient muscle and may have a role in a therapeutic strategy for Duchenne muscular dystrophy. This has resulted in many investigations of the full-length muscle form of utrophin; however, the short utrophins and non-muscle forms have been relatively neglected, partly because they are ...
Jimenez-Mallebrera C, Davies K, Putt W, Edwards YH   +3 more
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Utrophin: A potential replacement for dystrophin?

Neuromuscular Disorders, 1993
This paper reviews the evidence that utrophin, the autosomally encoded protein related to dystrophin, may be capable of performing the same cellular functions as dystrophin. If this is the case, it may be possible to modify the regulation of utrophin expression as an alternative route to dystrophin gene therapy for sufferers of DMD and/or BMD.
J M, Tinsley, K E, Davies
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Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice

Nature Genetics, 1998
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease usually resulting in death of patients by their early twenties. In contrast, mice lacking dystrophin (Dmd(mdx)), appear physically normal despite their underlying muscle pathology.
J A, Rafael, J M, Tinsley, A C, Potter, A E, Deconinck, K E, Davies   +4 more
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Utrophin is a calpain substrate in muscle cells

Muscle & Nerve, 2006
AbstractCalpains are Ca2+‐dependent cytosolic cysteine proteases that participate in the pathology of Duchenne muscular dystrophy (DMD). Utrophin is a functional homolog of dystrophin that partially compensates for dystrophin deficiency in myofibers of mdx mice.
Isabelle, Courdier-Fruh, Alexandre, Briguet   +1 more
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Utrophin muscles in on the action

Nature Medicine, 1997
Overexpressing utrophin in muscles may prove a promising strategy for treating Duchenne muscular dystrophy but many questions remain unanswered.
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