Results 71 to 80 of about 7,758 (250)

Role of dystrophins and utrophins in platelet adhesion process [PDF]

British Journal of Haematology, 2006
SummaryPlatelets are crucial at the site of vascular injury, adhering to the sub‐endothelial matrix through receptors on their surface, leading to cell activation and aggregation to form a haemostatic plug. Platelets display focal adhesions as well as stress fibres to contract and facilitate expulsion of growth and pro‐coagulant factors contained in ...
Ricardo Mondragón, Bulmaro Cisneros, Francisco Martínez-Pérez, Dalila Martínez-Rojas, Doris Cerecedo, Alvaro Rendon   +5 more
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, Volume 599, Issue 20, Page 2878-2895, October 2025.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy [PDF]

, 2017
Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials.
, Bello, Luca, Gordish-Dressman, Heather, Head, Stewart I., Hoffman, Eric P., Hogarth, Marshall W., Houweling, Peter J., North, Kathryn N., Pegoraro, Elena, Thomas, Kristen C.   +9 more
core   +2 more sources

Microtubule binding distinguishes dystrophin from utrophin [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Our in vitro analyses reveal that dystrophin, the protein absent in Duchenne muscular dystrophy patients, binds microtubules with high affinity and pauses microtubule polymerization, whereas utrophin, the autosomal homologue of dystrophin thought to mirror many known functions of dystrophin, has no activity in either assay.
Michael D. Eckhoff, Dana M. Strandjord, Glen B. Banks, Dawn A. Lowe, Tara L. Mader, Melissa K. Gardner, James M. Ervasti, Joseph J. Belanto   +7 more
openaire   +3 more sources

An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate

Developmental Dynamics, Volume 254, Issue 10, Page 1115-1132, October 2025.
Abstract Background The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial surface of the neural plate as internalization begins to form the neural keel in the hindbrain region of the zebrafish embryo.
Claudio Araya, Raegan Boekemeyer, Francesca Farlie, Lauren Moon, Freshta Darwish, Chris Rookyard, Leanne Allison, Gema Vizcay‐Barrena, Roland Fleck, Millaray Aranda, Masa Tada, Jonathan D. W. Clarke   +11 more
wiley   +1 more source

Dystroglycan versatility in cell adhesion: a tale of multiple motifs [PDF]

, 2010
Dystroglycan is a ubiquitously expressed heterodimeric adhesion receptor. The extracellular a-subunit makes connections with a number of laminin G domain ligands including laminins, agrin and perlecan in the extracellular matrix and the transmembrane b-
A Ivetic, A Sgambato, A Waite, AJ Baines, AM Belkin, AS Yatsenko, AS Yatsenko, Avd Flier, B Casar, B Casar, B Yang, C Anderson, C Anderson, C Batchelor, C Berthier, C Losasso, C Moore, C Vanni, Chris J Moore, CL Batchelor, CL Batchelor, CM Gould, ED Apel, F Sotgia, F Sotgia, F Sotgia, FM Pavalko, GA Rezniczek, GC Dobbins, HJ Spence, HJ Spence, HJ Spence, J Iida, J Kahl, JCR Jones, JL Ilsley, JL Ilsley, JS Poulton, JW Legg, K Iida, K Russo, K Sumita, K Takahashi, K Takahashi, KJ Langenbach, KR Legate, L Fuentes-Mera, L Heiska, M Bartoli, M Bozzi, M Cavaldesi, M Durbeej, M Durbeej, M Ferletta, M Gautam, M James, M Schneider, M Villarreal-Silva, M Weir, ML Oppizzi, NR Smalheiser, NR Smalheiser, O Ibraghimov-Beskrovnaya, O Thompson, O Thompson, R González-Ramírez, RA Williamson, RM Grady, RO Hynes, S Cross, S Yonemura, SA Oak, SH Gee, SJ Winder, SJ Winder, Steve J Winder, T Haenggi, T Muranen, T Rando, V Mirouse, VJ Fincham, W-M Deng, X Yongmin, Y Lai, Y-J Chen, YW Zhou   +85 more
core   +3 more sources

Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition

Communications Biology, 2023
With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.
Hannah J. Gleneadie, Beatriz Fernandez-Ruiz, Alessandro Sardini, Mathew Van de Pette, Andrew Dimond, Rab K. Prinjha, James McGinty, Paul M. W. French, Hakan Bagci, Matthias Merkenschlager, Amanda G. Fisher   +10 more
doaj   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, Volume 292, Issue 19, Page 5067-5085, October 2025.
Duchenne muscular dystrophy is a severe neuromuscular wasting disease that is caused by a primary defect in dystrophin protein. A targeted mass‐spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy.
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Subtle Neuromuscular Defects in Utrophin-deficient Mice [PDF]

The Journal of Cell Biology, 1997
Utrophin is a large cytoskeletal protein that is homologous to dystrophin, the protein mutated in Duchenne and Becker muscular dystrophy. In skeletal muscle, dystrophin is broadly distributed along the sarcolemma whereas utrophin is concentrated at the neuromuscular junction.
Joshua R. Sanes, R. Mark Grady, John P. Merlie   +2 more
openaire   +3 more sources

l-arginine improves dystrophic phenotype in mdx mice

Neurobiology of Disease, 2005
A possible treatment for Duchenne muscular dystrophies would be to compensate for dystrophin loss by increasing the expression of utrophin, another cytoskeletal protein of the muscle membrane. We previously found that l-arginine, the substrate for nitric
Vincent Voisin, Catherine Sébrié, Stéfan Matecki, Hua Yu, Brigitte Gillet, Michèle Ramonatxo, Maurice Israël, Sabine De la Porte   +7 more
doaj   +1 more source