Results 81 to 90 of about 7,799 (249)

l-arginine improves dystrophic phenotype in mdx mice

Neurobiology of Disease, 2005
A possible treatment for Duchenne muscular dystrophies would be to compensate for dystrophin loss by increasing the expression of utrophin, another cytoskeletal protein of the muscle membrane. We previously found that l-arginine, the substrate for nitric
Vincent Voisin, Catherine Sébrié, Stéfan Matecki, Hua Yu, Brigitte Gillet, Michèle Ramonatxo, Maurice Israël, Sabine De la Porte   +7 more
doaj   +1 more source

Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice [PDF]

, 2017
Aims Duchenne muscular dystrophy (DMD) is a severe striated muscle disease due to the absence of dystrophin. Dystrophin deficiency results in dysfunctional sodium channels and conduction abnormalities in hearts of mdx mice. Disease progression in the mdx
Abriel, Hugues, Albesa, Maxime, Ogrodnik, Jakob, Rougier, Jean-Sébastien   +3 more
core  

Visualization of actin filaments and monomers in somatic cell nuclei [PDF]

, 2013
© The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 24 (2013): 982-994, doi:10.1091/mbc.E12-09-0685.In addition to its long-
Belin, Brittany J., Blackburn, Elizabeth H., Cimini, Beth A., Mullins, R. Dyche   +3 more
core   +1 more source

Role of dystrophins and utrophins in platelet adhesion process [PDF]

British Journal of Haematology, 2006
SummaryPlatelets are crucial at the site of vascular injury, adhering to the sub‐endothelial matrix through receptors on their surface, leading to cell activation and aggregation to form a haemostatic plug. Platelets display focal adhesions as well as stress fibres to contract and facilitate expulsion of growth and pro‐coagulant factors contained in ...
Doris, Cerecedo, Ricardo, Mondragón, Bulmaro, Cisneros, Francisco, Martínez-Pérez, Dalila, Martínez-Rojas, Alvaro, Rendón   +5 more
openaire   +2 more sources

Cytokine Engineering Approaches for Regenerative Medicine

Advanced Therapeutics, Volume 8, Issue 9, September 2025.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

Identification of new dystroglycan complexes in skeletal muscle. [PDF]

PLoS ONE, 2013
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extracellular mucin-like protein α-dystroglycan. In skeletal muscle fibers, the dystroglycan complex plays an important structural role by linking the ...
Eric K Johnson, Bin Li, Jung Hae Yoon, Kevin M Flanigan, Paul T Martin, James Ervasti, Federica Montanaro   +6 more
doaj   +1 more source

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Microtubule binding distinguishes dystrophin from utrophin [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Our in vitro analyses reveal that dystrophin, the protein absent in Duchenne muscular dystrophy patients, binds microtubules with high affinity and pauses microtubule polymerization, whereas utrophin, the autosomal homologue of dystrophin thought to mirror many known functions of dystrophin, has no activity in either assay.
Joseph J, Belanto, Tara L, Mader, Michael D, Eckhoff, Dana M, Strandjord, Glen B, Banks, Melissa K, Gardner, Dawn A, Lowe, James M, Ervasti   +7 more
openaire   +2 more sources

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Incidence and Immunopathology of Myositis in Rectal Cancer Patients Treated With Neoadjuvant Immune Checkpoint Inhibitors and Chemoradiotherapy: Findings From the CHINOREC Trial

MedComm, Volume 6, Issue 7, July 2025.
ICI‐induced myositis occurred at a higher‐than‐expected rate (12%) in neoadjuvant‐treated rectal cancer patients receiving CRT+ICI. Elevated cTnT, but not cTnI, differentiated skeletal from cardiac involvement. Immunopathology showed a predominant CD8+ T cell infiltrate, highlighting a T cell‐mediated mechanism that necessitates early detection and ...
Rebecca Zirnbauer, Simon Hametner, Jutta Bergler‐Klein, Irene Kuehrer, Askin Kulu, Daphni Ammon, Julijan Kabiljo, Anton Stift, Rainer Schmid, Leonhard Müllauer, Clemens Bittermann, Friedrich Laengle, Klaus Machold, Stephan Blüml, Michael Bergmann, Johannes Laengle   +15 more
wiley   +1 more source