Results 81 to 90 of about 7,758 (250)

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy [PDF]

, 2013
SIRT1 is a metabolic sensor and regulator in various mammalian tissues and functions to counteract metabolic and age-related diseases. Here we generated and analyzed mice that express SIRT1 at high levels specifically in skeletal muscle.
Chalkiadaki, Angeliki, Guarente, Leonard Pershing, Igarashi, Masaki, Knezevic, Jovana, Nasamu, Armiyaw Sebastian   +4 more
core   +3 more sources

Cytokine Engineering Approaches for Regenerative Medicine

Advanced Therapeutics, Volume 8, Issue 9, September 2025.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Utrophin gets a new look

The Journal of Cell Biology, 2002
![Graphic][1] Utrophin (green) can bind to actin (light blue) in two different modes.Utrophin, a member of the spectrin superfamily of actin-binding proteins ubiquitously expressed in human cells, helps link the actin cytoskeleton to the extracellular matrix. Galkin et al.
openaire   +3 more sources

Identification of new dystroglycan complexes in skeletal muscle. [PDF]

PLoS ONE, 2013
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extracellular mucin-like protein α-dystroglycan. In skeletal muscle fibers, the dystroglycan complex plays an important structural role by linking the ...
Eric K Johnson, Bin Li, Jung Hae Yoon, Kevin M Flanigan, Paul T Martin, James Ervasti, Federica Montanaro   +6 more
doaj   +1 more source

Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice [PDF]

, 2017
Aims Duchenne muscular dystrophy (DMD) is a severe striated muscle disease due to the absence of dystrophin. Dystrophin deficiency results in dysfunctional sodium channels and conduction abnormalities in hearts of mdx mice. Disease progression in the mdx
Abriel, Hugues, Albesa, Maxime, Ogrodnik, Jakob, Rougier, Jean-Sébastien   +3 more
core  

Incidence and Immunopathology of Myositis in Rectal Cancer Patients Treated With Neoadjuvant Immune Checkpoint Inhibitors and Chemoradiotherapy: Findings From the CHINOREC Trial

MedComm, Volume 6, Issue 7, July 2025.
ICI‐induced myositis occurred at a higher‐than‐expected rate (12%) in neoadjuvant‐treated rectal cancer patients receiving CRT+ICI. Elevated cTnT, but not cTnI, differentiated skeletal from cardiac involvement. Immunopathology showed a predominant CD8+ T cell infiltrate, highlighting a T cell‐mediated mechanism that necessitates early detection and ...
Rebecca Zirnbauer, Simon Hametner, Jutta Bergler‐Klein, Irene Kuehrer, Askin Kulu, Daphni Ammon, Julijan Kabiljo, Anton Stift, Rainer Schmid, Leonhard Müllauer, Clemens Bittermann, Friedrich Laengle, Klaus Machold, Stephan Blüml, Michael Bergmann, Johannes Laengle   +15 more
wiley   +1 more source

Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype.

PLoS ONE, 2008
We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response.
Kurt W Prins, Dawn A Lowe, James M Ervasti   +2 more
doaj   +1 more source

Obligatory and accessory respiratory muscle structure, function and control in early and advanced disease in the mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, Volume 603, Issue 14, Page 4113-4152, 15 July 2025.
Abstract figure legend We examined obligatory (diaphragm, external intercostal and parasternal) and accessory (sternomastoid, cleidomastoid, scalene and trapezius) muscle form, function and control in early (4 months) and advanced (16 months) dystrophic disease. Peak inspiratory pressure is preserved in 4‐month‐old mdx mice but is decreased in 16‐month‐
Aoife D. Slyne, David P. Burns, Karina Wöller, Amandine May, Roisin Dowd, Sarah E. Drummond, Grzegorz Jasionek, Ken D. O'Halloran   +7 more
wiley   +1 more source

The Utrophin Gene Is Transcriptionally Up-regulated in Regenerating Muscle

Journal of Biological Chemistry, 2002
The utrophin gene codes for a large cytoskeletal protein closely related to dystrophin, the gene mutated in Duchenne's muscular dystrophy. Although utrophin could functionally substitute for dystrophin, in Duchenne's muscular dystrophy patients it did not compensate for the absence of dystrophin because in adult muscle utrophin was poorly expressed and
GALVAGNI F., CANTINI M., OLIVIERO, Salvatore   +2 more
openaire   +5 more sources