Results 81 to 90 of about 7,812 (251)

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
EVs were isolated from plasma of ME/CFS patients and healthy controls at baseline, and 15 min and 24 h postexercise. Untargeted proteomics revealed dysregulation in energy metabolism, the complement system, and the endoplasmic reticulum stress response. Changes in EV protein levels postexercise are associated with post‐exertional malaise.
Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson   +3 more
wiley   +1 more source

Utrophin gets a new look

The Journal of Cell Biology, 2002
![Graphic][1] Utrophin (green) can bind to actin (light blue) in two different modes.Utrophin, a member of the spectrin superfamily of actin-binding proteins ubiquitously expressed in human cells, helps link the actin cytoskeleton to the extracellular matrix. Galkin et al.
openaire   +3 more sources

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

Advanced Science, Volume 12, Issue 16, April 24, 2025.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka   +7 more
wiley   +1 more source

Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true? [PDF]

, 2018
Extraocular muscles (EOM) are typically spared in Duchenne muscular dystrophy. We hypothesized that this might be due to different patterns of utrophin expression.
Assadi, Maziar, Müntener, Markus
core  

Dystroglycan versatility in cell adhesion: a tale of multiple motifs [PDF]

, 2010
Dystroglycan is a ubiquitously expressed heterodimeric adhesion receptor. The extracellular a-subunit makes connections with a number of laminin G domain ligands including laminins, agrin and perlecan in the extracellular matrix and the transmembrane b-
A Ivetic, A Sgambato, A Waite, AJ Baines, AM Belkin, AS Yatsenko, AS Yatsenko, Avd Flier, B Casar, B Casar, B Yang, C Anderson, C Anderson, C Batchelor, C Berthier, C Losasso, C Moore, C Vanni, Chris J Moore, CL Batchelor, CL Batchelor, CM Gould, ED Apel, F Sotgia, F Sotgia, F Sotgia, FM Pavalko, GA Rezniczek, GC Dobbins, HJ Spence, HJ Spence, HJ Spence, J Iida, J Kahl, JCR Jones, JL Ilsley, JL Ilsley, JS Poulton, JW Legg, K Iida, K Russo, K Sumita, K Takahashi, K Takahashi, KJ Langenbach, KR Legate, L Fuentes-Mera, L Heiska, M Bartoli, M Bozzi, M Cavaldesi, M Durbeej, M Durbeej, M Ferletta, M Gautam, M James, M Schneider, M Villarreal-Silva, M Weir, ML Oppizzi, NR Smalheiser, NR Smalheiser, O Ibraghimov-Beskrovnaya, O Thompson, O Thompson, R González-Ramírez, RA Williamson, RM Grady, RO Hynes, S Cross, S Yonemura, SA Oak, SH Gee, SJ Winder, SJ Winder, Steve J Winder, T Haenggi, T Muranen, T Rando, V Mirouse, VJ Fincham, W-M Deng, X Yongmin, Y Lai, Y-J Chen, YW Zhou   +85 more
core   +3 more sources

Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes

Journal of Neurochemistry, Volume 169, Issue 4, April 2025.
Glycine receptors (GlyRs) play key roles in brain development, learning/memory, inflammatory pain sensitization, and rhythmic breathing. GlyRs depend upon stable and transient protein–protein interactions that influence synaptic localization, homeostasis, signaling pathways, and receptor function.
Sean D. Fraser, Remco V. Klaassen, Carmen Villmann, August B. Smit, Robert J. Harvey   +4 more
wiley   +1 more source

Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype.

PLoS ONE, 2008
We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response.
Kurt W Prins, Dawn A Lowe, James M Ervasti   +2 more
doaj   +1 more source

Functional characterisation of filamentous actin probe expression in neuronal cells. [PDF]

PLoS ONE, 2017
Genetically encoded filamentous actin probes, Lifeact, Utrophin and F-tractin, are used as tools to label the actin cytoskeleton. Recent evidence in several different cell types indicates that these probes can cause changes in filamentous actin dynamics,
Shrujna Patel, Sandra Y Y Fok, Holly Stefen, Tamara Tomanić, Esmeralda Parić, Rosanna Herold, Merryn Brettle, Aleksandra Djordjevic, Thomas Fath   +8 more
doaj   +1 more source

Astrocyte proliferation in the hippocampal dentate gyrus is suppressed across the lifespan of dystrophin‐deficient mdx mice

Experimental Physiology, Volume 110, Issue 4, Page 585-598, 1 April 2025.
Abstract Absence of the structural protein, dystrophin, results in the neuromuscular disorder Duchenne Muscular Dystrophy (DMD). In addition to progressive skeletal muscle dysfunction, this multisystemic disorder can also result in cognitive deficits and behavioural changes that are likely to be consequences of dystrophin loss from central neurons and ...
Kimberley A. Stephenson, Polly Peters, Mark G. Rae, Dervla O'Malley   +3 more
wiley   +1 more source

Utrophin localization in normal and dystrophin-deficient heart. [PDF]

Circulation, 1994
BACKGROUND The localization of dystrophin at the sarcolemma of cardiac skeletal fibers and cardiac Purkinje fibers has been described. Dystrophin deficiency produces clinical manifestations of disease in skeletal muscles and hearts of patients with Duchenne and Becker muscular dystrophy. Utrophin (or dystrophin-related protein),
Pons, Françoise, Robert, Agnès, Fabbrizio, Eric, Hugon, Gerald, Califano, Jean-Christophe, Fehrentz, Jean-Alain, Martinez, Jean, Mornet, Dominique   +7 more
openaire   +3 more sources