Results 81 to 90 of about 40,730 (262)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Rifabutin corneal deposits localized to the deep stroma using anterior segment optical coherence tomography. [PDF]

, 2020
Purpose:To demonstrate that rifabutin-related corneal deposits are localized to the deep stroma using anterior segment optical coherence tomography (OCT) and confocal microscopy.
Lin, Yijie B, Schallhorn, Julie M, Sun, Catherine Q, Zhang, Tianyi   +3 more
core  

Complications at Diagnosis of Pediatric Chronic Myeloid Leukemia in Chronic Phase

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Chronic myeloid leukemia (CML) is uncommon during the first two decades of life, resulting in limited experience of pediatricians in handling this leukemia. This is even more true when it comes to managing rare complications at the time of diagnosis.
Nirmalya Roy Moulik, Uma Athale, Markus Metzler, Frederic Millot, Meinolf Suttorp   +4 more
wiley   +1 more source

Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III [PDF]

, 2018
PURPOSE: To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. DESIGN: Phase 3, open-label, multicenter clinical trial extension (VISUAL III).
Adán, A, Brézin, AP, Camez, A, Cimino, L, Dick, AD, Fortin, E, Goto, H, Jaffe, GJ, Kaburaki, T, Kramer, M, Kron, M, Lim, LL, Liu, J, Muccioli, C, Nguyen, QD, Pathai, S, Schlaen, A, Song, AP, Suhler, EB, Tari, S, Van Calster, J, van Velthoven, MEJ, Vitale, AT, Zierhut, M   +23 more
core   +1 more source

Sphingosine‐1‐Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety

United European Gastroenterology Journal, EarlyView.
ABSTRACT Ulcerative colitis is a chronic immune‐mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate‐to‐severe ulcerative colitis, significantly improving its management.
Massimo C. Fantini, Diego Centonze, Giovanni Giacobazzi, Silvia Benemei, Emanuele Romeo   +4 more
wiley   +1 more source

Spectral domain optical coherence tomography as an adjunctive tool for screening Behçet uveitis.

PLoS ONE, 2018
BackgroundThis study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME).MethodsThis retrospective, interventional study included a total 131 ...
Hae Min Kang, Hyoung Jun Koh, Sung Chul Lee   +2 more
doaj   +1 more source

Changing uveitis patterns in South India - Comparison between two decades

Indian Journal of Ophthalmology, 2018
Purpose: Changing pattern of uveitis in a subset of a population is an important ocular health indicator. Methods: A comparative study was done between uveitis patients of 2013 and 1995 using two proportions Z-test.
Jyotirmay Biswas, Ranju Kharel (Sitaula), Priyansha Multani   +2 more
doaj   +1 more source

The use of x-ray CT and MRI in the study of sacroiliac joints in patients with Behcet disease and acute anterior uveitis [PDF]

, 2018
Objective: It's controversial if Behcet Disease (BD) must be included in the group of seronegative spondyloarthropathy (SpA). Our aim was to establish the prevalence of sacroiliitis (SI) in patients with BD using X-Ray, CT and MRI, in comparison with ...
CODACCI PISANELLI, Massimo, Costi, Umberto, DE SANTIS, Anna, Gabriele, Raimondo, Izzo, Luciano, Izzo, Paolo, Izzo, Sara, Pugliese, Federico, Valabrega, Stefano   +8 more
core   +1 more source

Effectiveness and Safety of Advanced Dual‐Targeted Therapy in Refractory Perianal Crohn's Disease

United European Gastroenterology Journal, EarlyView.
ABSTRACT Introduction Perianal Crohn's disease (CD) remains challenging to treat despite the increasing number of advanced therapies. Advanced dual‐targeted therapy has emerged as a new treatment option in CD, but no data are available for perianal CD. The aim of this study was to evaluate the effectiveness and safety of advanced dual‐targeted therapy ...
Nadia Fathallah, Mario Pagano, Mohamed Amine Haouari, Amélie Barré, Calina Atanasiu, Edouard Chambenois, Isabelle Nion‐Larmurier, Stéphane Morisset, Julien Kirchgesner, Vincent de Parades   +9 more
wiley   +1 more source

Pattern of uveitis in a referral uveitis clinic in India

Indian Journal of Ophthalmology, 1995
The pattern of uveitis changes over time with the emergence or identification of new uveitic entities. The aim of this prospective study was to obtain a correct incidence pattern and aetiology of uveitis cases seen in a uveitis clinic. We studied all new
Das Debashis, Biswas Jyotirmay, Ganesh Sudha   +2 more
doaj