Results 1 to 10 of about 12,508 (157)

Original paper Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis [PDF]

Rheumatology, 2015
Introduction: Human leukocyte antigen B27 (HLA-B27) is considered as a risk factor for development of juvenile idiopathic arthritis (JIA). The aim of this study was to analyse the prevalence of HLA-B27 antigen in JIA categories and its influence on ...
Zbigniew Żuber, Dorota Turowska-Heydel, Małgorzata Sobczyk, Jerzy Chudek   +3 more
doaj   +6 more sources

HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps [PDF]

BMC Musculoskeletal Disorders, 2017
Background Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population.
Nelly Raymond Ziade
doaj   +2 more sources

Autoinflammation and HLA-B27: Beyond Antigen Presentation [PDF]

Ocular Immunology and Inflammation, 2016
HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more ...
Cailin Sibley
exaly   +3 more sources

Does HLA-B27 Status Influence Ixekizumab Efficacy in Axial Spondyloarthritis? Results From the COAST-V, COAST-W, and COAST-X Trials [PDF]

Rheumatology and Therapy
Introduction The human leukocyte antigen (HLA)-B27 is associated with axial spondyloarthritis (axSpA) and is a predictor of response to tumor necrosis factor inhibitors. However, limited data are available on HLA-B27 and interleukin-17 inhibitors.
John D. Reveille, Martin Rudwaleit, Proton Rahman, Jose A. Maldonado-Cocco, Marina Magrey, Rebecca Bolce, Khai Jing Ng, Theresa Hunter Gibble, Jeffrey Lisse, So Young Park, Andris Kronbergs, Victoria Navarro-Compán   +11 more
doaj   +2 more sources

The Frequency of HLA-B27 Antigen Positivity in Patients with Rheumatoid Arthritis and Anklylosing Spondylitis and The Relationship Between HLA-B27 Antigen and Other Autoantibodies

Hitit Medical Journal
Objective: The aim of this study was to research the frequency of Human Leukocyte Antigen (HLA)-B27 antigen positivity and relationship between HLA-B27 positivity and other autoantibodies and between HLA-B27 positivity and ...
Gülseren Demir Karakılıç, Esra Şahingöz Bakırcı, Ferda Büyük   +2 more
doaj   +3 more sources

HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation [PDF]

Gut Microbes
Ankylosing spondylitis (AS) is strongly associated with the human leukocyte antigen B27 (HLA-B27), yet how this genetic risk factor interacts with the gut microbiome remains unclear.
Tianwen Huang, Hang Yang, Lingshu Zhang, Xiangpeng Wang, Ye Chen, Huanzi Dai, Kenji Hashimoto, Yubin Luo, Yaoyu Pu, Yi Liu   +9 more
doaj   +2 more sources

Association of HLA-B27 antigen with clinical and laboratory parameters in patients with juvenile idiopathic arthritis [PDF]

Medicinski Glasnik, 2023
Aim To analyse the association of human leukocyte antigen B27 with clinical and laboratory parameters in patients with juvenile idiopathic arthritis (JIA) at the disease onset. Methods A retrospective review of medical records of 25 HLAB27 positive and
Adisa Čengić, Velma Selmanović, Sniježana Hasanbegović, Nedim Begić, Emina Karčić, Elma Fejzić   +5 more
doaj   +1 more source

HLA-B27 (antigen) in retroperitoneal fibrosis in a family

Archives of Medical Science, 2007
Idiopathic retroperitoneal fibrosis is a rare disease of undetermined aetiology. It is important to distinguish this entity from retroperitoneal fibrosis secondary to malignancy or specific inflammatory disease.
Mohammad Yazdani, Afshin Shadmehr
doaj   +1 more source

Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study

Pediatric Rheumatology Online Journal, 2023
Background The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA).
Suvi Oili Orvokki Peltoniemi, Mia Glerup, Pekka Lahdenne, Kari K Eklund, Kristiina Aalto   +4 more
doaj   +1 more source

Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules

Frontiers in Immunology, 2022
Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format, composed of a specific peptide fused to the light chain beta-2 microglobulin (β2m) and MHC class I heavy chain (HC) by ...
Izabela Lenart, Izabela Lenart, Izabela Lenart, Linh-Huyen Truong, Linh-Huyen Truong, Dinh Dung Nguyen, Dinh Dung Nguyen, Olga Rasiukienė, Edward Tsao, Jonathan Armstrong, Pankaj Kumar, Kirsty McHugh, Kirsty McHugh, Branca I. Pereira, Branca I. Pereira, Branca I. Pereira, Balraj S. Maan, Balraj S. Maan, Malgorzata A. Garstka, Paul Bowness, Neil Blake, Simon J. Powis, Keith Gould, Darren Nesbeth, Antony N. Antoniou, Antony N. Antoniou   +25 more
doaj   +1 more source