Results 41 to 50 of about 499,322 (218)

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
core   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

Impact of Dual Interleukin‐17A and Interleukin‐17F Inhibition with Bimekizumab on Inflammatory and Structural Lesions in Axial Spondyloarthritis: MRI and Radiographic Outcomes from the Phase 3 BE MOBILE 1 and 2 Studies and their Open‐Label Extension

Arthritis &Rheumatology, Accepted Article.
Objectives To evaluate the impact of bimekizumab, a dual IL‐17A and IL‐17F inhibitor, on sacroiliac joint (SIJ) and spine inflammation/structural damage in axSpA using MRIs/radiographs from the phase 3 studies BE MOBILE 1 (nr‐axSpA) and 2 (r‐axSpA) and their open‐label extension (OLE).
Walter P. Maksymowych, Sofia Ramiro, Denis Poddubnyy, Xenofon Baraliakos, Robert G.W. Lambert, Ute Massow, Tom Vaux, Chetan Prajapati, Alexander Marten, Natasha de Peyrecave, Mikkel Østergaard   +10 more
wiley   +1 more source

Characterisation of the oxidoreductase Erol-Lß and the misfolding of the secretory pathway substrate HLA-B27 [PDF]

, 2007
The endoplasmic reticulum (ER) is the site of oxidative folding for proteins entering the secretory pathway. Here, nascent polypeptides acquire disulfide bonds, which confer both stability and functionality on secretory and ER-resident proteins.
Lemin, Andrew James
core  

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross‐Reactive Groups and Human Platelet Antigens

Journal of Clinical Laboratory Analysis, EarlyView.
This assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Huimin Ji, Kaihao Feng, Yunping Xu, Le Chang, Ying Yan, Jie Ma, Yi Liu, Jinfeng Zeng, Huizhen Sun, Lunan Wang   +9 more
wiley   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Tabaczewski, P., Pohla, Heike, Heike Pohla, Kuon, W., Wolfgang Kuon, Piotr Tabaczewski, Doerner, C., Weiss, Elisabeth H., Christa Doerner, Elisabeth H. Weiss   +9 more
core   +1 more source

Altered regulation of ELAVL1/HuR in HLA-B27-expressing U937 monocytic cells. [PDF]

PLoS ONE, 2013
To investigate the role of HLA-B27 expression in the regulation of RNA binding protein (RBP) Embryonic Lethal Abnormal Vision (ELAV) L1/Human antigen R (HuR) expression in Salmonella-infected or LPS-stimulated human monocytic cells, since HuR is a ...
Anna S Sahlberg, Marja Ruuska, Kaisa Granfors, Markus A Penttinen   +3 more
doaj   +1 more source

Hla‐c locus antigens in hla‐b27 associated arthritis [PDF]

Arthritis & Rheumatism, 1978
AbstractFrequecies of the HLA‐C locus antigens, Cw 1, Cw2, Cw3, and Cw4, were determined in 88 patients with spondylitic diseases and 88 matched and 64 B27‐positive normal controls. Both Cw1 and Cw2 were significantly increased in B27‐positive patients and B27‐positive controls as compared to B27‐negative patients and matched controls.
F C, Arnett, M C, Hochberg, W B, Bias
openaire   +2 more sources

Pediatric Systemic Lupus Erythematosus Complicated by Acute EBV and CMV Co‐infection

Journal of Clinical Laboratory Analysis, EarlyView.
This case report describes a 10‐year‐old girl with new‐onset pediatric SLE who presented with malar rash, fever, and arthritis following sun exposure, alongside serological evidence of acute Epstein–Barr virus (EBV) and cytomegalovirus (CMV) co‐infection.
Anning Chen, Gengchun Ji, Ziping Lan, Ping Li, Jianwei Wang, Le Zhang, Chaojun Hu, Shulan Zhang   +7 more
wiley   +1 more source

An investigation into the consequences of Salmonella infection of murine macrophages and dendritic cells: relevance to reactive arthritis. [PDF]

, 2006
Reactive arthritis (ReA) is a sterile joint inflammation triggered by bacterial infection and is associated with the MHC class I molecule HLA-B27. Bacterial antigens have been detected in synovial tissues from ReA patients, but how they are transported ...
Zhao, C., Zhao, Chun Fang
core