Results 61 to 70 of about 548,741 (210)

Systemic treatments of patients with HLA-B27-associated uveitis.

, 2020
Systemic treatments of patients with HLA-B27-associated uveitis.
Pierre Pradat (816487), Roland Chapurlat (283094), Nabil Bouzid (8648571), Laurent Kodjikian (5488115), Yvan Jamilloux (436733), Audrey De Parisot (8648574), Pascal Sève (4449340)   +6 more
core   +1 more source

Prevalence of Human Leukocyte Antigen B27 Positivity and Microbiological Profiles of Patients with Reactive Arthritis – A Cross Sectional Study

, 2021
The present study aims to determine the spectrum of etiological agents and to screen HLA-B27 and, related inflammatory markers in patients presenting with symptoms of Spondyloarthritis(SpA) post diarrhea, which can aid in prompt diagnosis of reactive ...
A. Sundaram, K. V. Leela, R. Aparna, T. Jayaprakash, C. Panchapakesa Rajendran, K.V. Leela   +5 more
core   +1 more source

Determination of HLA-B27 Subtypes in Iranian Patients with Ankylosing Spondylitis

Iranian Journal of Allergy, Asthma and Immunology, 2008
The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS).
Mohamad Hossein Nicknam, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mazdak Ganjalikhani Hakemi, Farideh Khosravi, Ahmad Reza Jamshidi, Aref Amirkhani, Bita Ansaripour, Zahra Pourpak, Mostafa Moin, Behrooz Nikbin   +10 more
doaj  

Generation of induced pluripotent stem cells from an HLA-B27 positive ankylosing spondylitis patient with syndesmophyte formation

Stem Cell Research
Human leukocyte antigen (HLA)-B27 is the genetic marker for ankylosing spondylitis (AS). Here, we generated induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells of a male AS patient carrying HLA-B27 with syndesmophyte formation ...
Wan-Hao Tsai, Yen-Chun Lin, Shih-Hsun Lan, Yu-Heng Lin, Chun-Hsiung Chen, Song-Chou Hsieh, Chin-Hsiu Liu   +6 more
doaj   +1 more source

Secukinumab in non-radiographic axial spondyloarthritis: subgroup analysis based on key baseline characteristics from a randomized phase III study, PREVENT

Arthritis Research & Therapy, 2021
Background To investigate the efficacy of secukinumab in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) grouped by disease activity as assessed by C-reactive protein (CRP) levels and/or magnetic resonance imaging (MRI) scores ...
Jürgen Braun, Ricardo Blanco, Helena Marzo-Ortega, Lianne S. Gensler, Filip van den Bosch, Stephen Hall, Hideto Kameda, Denis Poddubnyy, Marleen van de Sande, Anna S. Wiksten, Brian O. Porter, Abhijit Shete, Hanno B. Richards, Sibylle Haemmerle, Atul Deodhar   +14 more
doaj   +1 more source

Reduction of CXCR3+CCR6+ CD4+ T Cells and IL‐17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic ...
Addison Pacheco, Patricia Remalante‐Rayco, Nigil Haroon, Denis Poddubnyy, Robert D. Inman   +4 more
wiley   +1 more source

Does HLA-B27 Status Influence Ixekizumab Efficacy in Axial Spondyloarthritis? Results From the COAST-V, COAST-W, and COAST-X Trials

Rheumatology and Therapy
Introduction The human leukocyte antigen (HLA)-B27 is associated with axial spondyloarthritis (axSpA) and is a predictor of response to tumor necrosis factor inhibitors. However, limited data are available on HLA-B27 and interleukin-17 inhibitors.
John D. Reveille, Martin Rudwaleit, Proton Rahman, Jose A. Maldonado-Cocco, Marina Magrey, Rebecca Bolce, Khai Jing Ng, Theresa Hunter Gibble, Jeffrey Lisse, So Young Park, Andris Kronbergs, Victoria Navarro-Compán   +11 more
doaj   +1 more source

Comprehensive single‐cell profiling of monocytes in HLA‐B27‐positive ankylosing spondylitis with acute anterior uveitis

MedComm
Acute anterior uveitis (AAU) is a common extra‐articular manifestation of ankylosing spondylitis (AS), particularly in patients positive for the human leucocyte antigen (HLA)‐B27 genetic marker.
Huan Li, Xueming Ju, Lixin Zhang, Jing Zhu, Jing Zhang, Jialing Xiao, Ting Wang, Weijia Wu, Liang Wang, Chengzi Gan, Xiangmei Li, Yutong Wei, Siyu Zhu, Yu Zhou, Bolin Deng, Ning Xiao, Bo Gong   +16 more
doaj   +1 more source

Combined detection of HLA-B27, ESR, and CRP as biochemical and immunogenetic markers in the auxiliary diagnosis of ankylosing spondylitis [PDF]

Journal of Medical Biochemistry
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease in which early diagnosis is often challenging due to atypical clinical manifestations.
Wang Muchuan, Yao Siyuan, Gao Chengao, Wang Yipeng   +3 more
doaj   +1 more source

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross‐Reactive Groups and Human Platelet Antigens

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
This assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Huimin Ji, Kaihao Feng, Yunping Xu, Le Chang, Ying Yan, Jie Ma, Yi Liu, Jinfeng Zeng, Huizhen Sun, Lunan Wang   +9 more
wiley   +1 more source