Results 71 to 80 of about 499,322 (218)

NF1 Leucine Rich Domain‐Derived Extracellular Vesicles Remodel the Glioblastoma Immune Microenvironment via an ADAM17‐Associated Inflammatory Program

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
NF1‐LRD‐derived EVs suppress glioma cells' invasion and reprogram TAMs through the ADAM17‐TNFα‐ICAM‐1 signaling axis. These EVs reduce migration recruitment, enhance pro‐inflammatory polarization, and modulate key pathways, collectively reshaping the GBM TME. (Created with Biorender.com) ABSTRACT Extracellular vesicles (EVs) are increasingly recognized
Yuganthini Vijayanathan, Jacqueline YT Yeo, Janice HY Tan, Fikri Bin Mohamed, Bernett Lee, Tatsuya Kozaki, Nurashikin Abdul Halim, Rachel LY Ho, Hai Tao Tu, Zhi Wei Zhang, Jann N. Sarkaria, Li Zeng, Florent Ginhoux, Ivy AW Ho   +13 more
wiley   +1 more source

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study [PDF]

, 2009
Background: Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level.
Santiago Avila-Rios, Avila-Rios, S., Brumme, Z.L., Espinosa Enrique, Carlson, J.M., Valenzuela-Ponce Humberto, Carlson Jonathan M, John Mina, Ormsby Christopher E, David Heckerman, Heckerman, D., Juan Blanco-Heredia, Blanco-Heredia Juan, Mallal Simon, Brumme Zabrina L, Daniela Garrido-Rodriguez, Espinosa, E., Enrique Espinosa, Reyes-Teran Gustavo, Garrido-Rodriguez, D., Ormsby, C.E., Valenzuela-Ponce, H., Garcia-Morales Claudia, Zabrina L Brumme, John, M., Heckerman David, Simon Mallal, Gustavo Reyes-Teran, Claudia Garcia-Morales, Christopher E Ormsby, Humberto Valenzuela-Ponce, Garrido-Rodriguez Daniela, Avila-Rios Santiago, Mina John, Garcia-Morales, C., Jonathan M Carlson, Reyes-Teran, G., Blanco-Heredia, J., Mallal, S.   +38 more
core   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Development of a sample bank and clinical database for the retrospective analysis of unrelated bone marrow transplants: a pilot study of 138 transplants using RSCA for high resolution HLA matching. [PDF]

, 2005
The Anthony Nolan Register provides donors for allogeneic stem cell transplantation for haematological disorders. A clinical database and sample bank were established for the ongoing analysis of transplants from Register donors.
Pay, A.L.P.
core  

Atypical Case of Takayasu Aortitis Presenting as Embolic Stroke With Concomitant Massive Thoracic Artery Aneurysm

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Multifocal aortic aneurysmal dilatation as evidenced by CT Angiography chest‐abdomen‐pelvis of the ascending aorta (A), aortic arch (B), and suprarenal abdominal aorta (C), measuring 6.0 × 6.0, 4.5 × 4.5, and 4.1 × 3.7 cm, respectively. ABSTRACT We describe the case of a 44‐year‐old female with a history significant for only hypertension who presented ...
J. Curran Henson, Jordan H. Myers, Macy Cummins, Keyur Vyas, Michael Lowry   +4 more
wiley   +1 more source

A Case of Human Leukocyte Antigen (HLA) B27-Positive Intestinal Behçet's Disease with Crohn's Disease-Like Anal Fistulas

, 2014
A 49-year-old male was admitted to our hospital with complaints of perianal pain, bloody stool, and high-grade fever due to perianal abscess. Drainage was carried out; however, the patient's complaints worsened, and biopsy findings of colonoscopy showed ...
Yuki Nanke, Masakazu Takazoe, Shigeru Kotake, Kuniko Iihara, Tsuyoshi Kobashigawa, Hisashi Yamanaka   +5 more
core   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, Volume 59, Issue 7, July 2026.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

Métodos para la identificación del antígeno de histocompatibilidad HLA-B27: comparación de cuatro protocolos técnicos [PDF]

, 2015
La asociación del HLA-B27 y las Espondiloartritis, ha hecho evidente que la tipificación del HLA-B27 sea considerada como un apoyo en el diagnóstico de estas enfermedades.
Briceño, I, De Ávila, J., Muñoz, Dm, Briceño, I., Casas, Mc, Londono, John, Gómez G., A., Londoño, J, Maldonado, Z., Muñoz, Dm., Valle O., Rafael R., Romero Sánchez, C, Gómez G, A, Maldonado, Z, Bautista Molano, W., Bautista Molano, W, Ávila, J De, Romero Sánchez, C., Valle Oñate, R, Chila M, L, Chila M., L., Casas, Mc.   +21 more
core   +3 more sources

Comprehensive single‐cell profiling of monocytes in HLA‐B27‐positive ankylosing spondylitis with acute anterior uveitis

MedComm
Acute anterior uveitis (AAU) is a common extra‐articular manifestation of ankylosing spondylitis (AS), particularly in patients positive for the human leucocyte antigen (HLA)‐B27 genetic marker.
Huan Li, Xueming Ju, Lixin Zhang, Jing Zhu, Jing Zhang, Jialing Xiao, Ting Wang, Weijia Wu, Liang Wang, Chengzi Gan, Xiangmei Li, Yutong Wei, Siyu Zhu, Yu Zhou, Bolin Deng, Ning Xiao, Bo Gong   +16 more
doaj   +1 more source

Combined detection of HLA-B27, ESR, and CRP as biochemical and immunogenetic markers in the auxiliary diagnosis of ankylosing spondylitis [PDF]

Journal of Medical Biochemistry
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease in which early diagnosis is often challenging due to atypical clinical manifestations.
Wang Muchuan, Yao Siyuan, Gao Chengao, Wang Yipeng   +3 more
doaj   +1 more source