Results 31 to 40 of about 499,322 (218)

Human leukocyte antigen-B27: The genetic predisposition leading to reactive arthritis during induction phase chemotherapy for acute myeloid leukemia

Indian Journal of Medical and Paediatric Oncology, 2017
We report a case of reactive arthritis (ReA) during induction phase chemotherapy of a 15-year-old male patient with acute myeloid leukemia (AML) M4 with inv(16), most probably due to a genetic predisposition of being human leukocyte antigen b27 (HLA-B27)
Sandip P Bartakke, Abhilasha Ashok Sampagar, Vibha Sanjay Bafna, Putun Patel   +3 more
doaj   +1 more source

Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells. [PDF]

PLoS ONE, 2013
A tissue antigen, HLA-B27, is strongly associated with a group of rheumatic diseases called spondyloarthritides. Despite the intensive research, the exact role of HLA-B27 in the pathogenesis of these diseases is still unclear. Here we studied whether HLA-
Marja Ruuska, Anna S Sahlberg, Kaisa Granfors, Markus A Penttinen   +3 more
doaj   +1 more source

The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population

Frontiers in Immunology, 2022
ObjectivesHuman leucocyte antigen B27 (HLA-B27) is an important biomarker for ankylosing spondylitis (AS). However, delay in the diagnosis of AS is still common in clinical practice.
Nan Sheng, Nan Sheng, Nan Sheng, Yingying Gao, Hui Li, Wenwen Wang, Linyu Geng, Bo Zhang, Qiang Huang, Xueqin Wang, Lingyun Sun   +10 more
doaj   +1 more source

Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols [PDF]

, 2009
Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available.
Luceri, C., Castagnini, C., Martin, R., Evelo, C.T.; id_orcid, Zoetendal, E.G., Messerini, L., Eijssen, L., Caderni, G., Femia, A.P., Eijssen, L.M.; id_orcid, Renard, C.M., Giovannelli, L., Gaj, S., Evelo, C., Evelo, C.T., Bigagli, E., Baron, A., Toti, S., Lodovici, M., Salvadori, M., Dolara, P., Eijssen, L.M., Pitozzi, V.   +22 more
core   +2 more sources

HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Salmonella enterica serovar Enteritidis PT4 KS8822/88 replicates rapidly in HLA-B27-transfected human monocytic U937 cells. In this process, Salmonella pathogenicity island 2 (SPI-2) genes play a crucial role.
Shichao Ge, Qiushui He, Kaisa Granfors
doaj   +1 more source

Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules [PDF]

, 2011
The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest ...
Guiliano, D.B., Antoniou, A.N., Lenart, I.   +2 more
core   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection. [PDF]

, 2006
Chlamydia-specific cytotoxic T lymphocytes are able to control model infections but may be implicated in disease pathogenesis. HLA-A2 peptide tetramers to Chlamydia trachomatis major outer membrane protein 258-266 (MOMP258-266) and MOMP260-268 were used ...
Nkoyo Faal, Frederick Pemberton-Pigott, Hazel M. Dockrell, David C. W. Mabey, Martin J. Holland, Bailey, Robin L, Holland, Martin J, Pemberton-Pigott, Frederick, Joof, Hassan, Laye, Mass, Hassan Joof, Mass Laye, Sarr, Isatou, Ewen Cameron, Faal, Nkoyo, Isatou Sarr, Cameron, Ewen, Dockrell, Hazel M, Mabey, David CW, Robin L. Bailey   +19 more
core   +1 more source

Molecular Characterization of HLA-B27 in Anterior Uveitis: Integrated Serological and Genetic Analysis Reveals Elevated Antigen Levels and Variants Concentrated in Exons 2 and 3

Indonesian Biomedical Journal
BACKGROUND: Anterior uveitis is the most common form of intraocular inflammation and an important cause of visual morbidity worldwide. Human leukocyte antigen B27 (HLA-B27) is a well-established immunogenetic risk factor; however, its molecular diversity
Shinta Stri Ayuda Nur Setyaningsih, Arief Akhdestira Mustaram, Angga Fajriansyah, Patriotika Muslima, Elfa Ali Idrus, Muhammad Hamzah Syaifullah Azmi, Elsa Gustianty, Ernawati Arifin Giri-Rachman, Marselina Irasonia Tan   +8 more
doaj   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source