Results 1 to 10 of about 76 (56)

Biological characterization of the UW402, UW473, ONS-76 and DAOY pediatric medulloblastoma cell lines [PDF]

Cytotechnology, 2019
Medulloblastoma (MB) is the most common malignant brain tumor in children. Recent advances in molecular technologies allowed to classify MB in 4 major molecular subgroups: WNT, SHH, Group 3 and Group 4. In cancer research, cancer cell lines are important for examining and manipulating molecular and cellular process. However, it is important to know the
Ricardo Bonfim-Silva, Karina Bezerra Salomão, Thais Valéria Costa de Andrade Pimentel, Camila Cristina Branquinho de Olive Menezes, Patrícia Vianna Bonini Palma, Aparecida Maria Fontes   +5 more
europepmc   +13 more sources

The Florida Panther: Past, Present, and Future [PDF]

EDIS, 2015
The Florida panther was presumed extinct by the early 1950s, but was rediscovered in 1973 by a survey team organized by the National Geographic Society. They were one of the first species to be added to the US endangered species list and are now the only
David P. Onorato, Madan K. Oli, Madelon van de Kerk   +2 more
core   +9 more sources

Oxamate, but Not Selective Targeting of LDH-A, Inhibits Medulloblastoma Cell Glycolysis, Growth and Motility. [PDF]

Brain Sci, 2018
Medulloblastoma is the most common malignant paediatric brain tumour and current therapies often leave patients with severe neurological disabilities.
Valvona CJ, Fillmore HL.
europepmc   +4 more sources

Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup. [PDF]

Sci Rep, 2020
We evaluated the potential effects of ATO in different pediatric SHH-MB cell lines (ONS-76: TP53-wild type; DAOY and UW402: TP53-mutated). MB cell lines molecular subgroup was confirmed and TP53 mutations were validated. Cell viability, clonogenicity and
Dos Santos Klinger PH, Delsin LEA, Cruzeiro GAV, Andrade AF, Lira RCP, de Andrade PV, das Chagas PF, de Paula Queiroz RG, Trevisan FA, de Oliveira RS, Scrideli CA, Tone LG, Valera ET.   +12 more
europepmc   +3 more sources

Epigenetics and immune cells in medulloblastoma. [PDF]

Front Genet, 2023
: Medulloblastoma (MB) is a highly malignant childhood tumor of the cerebellum. Transcriptional and epigenetic signatures have classified MB into four molecular subgroups, further stratified into biologically different subtypes with distinct somatic copy-
Gorini F, Miceli M, de Antonellis P, Amente S, Zollo M, Ferrucci V.   +5 more
europepmc   +3 more sources

Human Sialic acid O-acetyl esterase (SIAE) - mediated changes in sensitivity to etoposide in a medulloblastoma cell line. [PDF]

Sci Rep, 2019
Medulloblastoma (MB), the most common malignant paediatric brain tumour occurs in the cerebellum. Advances in molecular genomics have led to the identification of defined subgroups which are associated with distinct clinical prognoses.
Mather RL, Loveson KF, Fillmore HL.
europepmc   +4 more sources

microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma. [PDF]

PLoS One, 2015
This study demonstrates the effects of miRNA-10b on medulloblastoma proliferation through transcriptional induction of the anti-apoptotic protein BCL2. Using a cancer specific miRNAarray, high expression of miRNA-10b inmedulloblastoma cell lines compared
Pal R, Greene S.
europepmc   +6 more sources

Chromosomal heterogeneity and instability characterize pediatric medulloblastoma cell lines and affect neoplastic phenotype. [PDF]

Cytotechnology, 2013
Chromosomal heterogeneity is a hallmark of most tumors and it can drive critical events as growth advantages, survival advantages, progression and karyotypic evolution.
Castro-Gamero AM, Borges KS, Lira RC, Andrade AF, Fedatto PF, Cruzeiro GA, Silva RB, Fontes AM, Valera ET, Bobola M, Scrideli CA, Tone LG.   +11 more
europepmc   +2 more sources

3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination [PDF]

, 2021
© 2021, The Author(s). Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblastoma ...
Coyle, Beth, Linke, Franziska, Roper, Sophie J., Scotting, Paul J.   +3 more
core   +2 more sources

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma [PDF]

, 2018
Summary: The brain cancer medulloblastoma consists of different transcriptional subgroups. To characterize medulloblastoma at the phosphoprotein-signaling level, we performed high-throughput peptide phosphorylation profiling on a large cohort of SHH ...
Bruggeman, Sophia W M, Conroy, Siobhan, de Bont, Eveline S J M, den Dunnen, Wilfred F A, Foijer, Floris, Gidding, Corrie E M, Guerrero Llobet, Sergi, Guryev, Victor, Hoving, Eelco W, Hulleman, Esther, Kruyt, Frank A E, Lourens, Harm J, Meeuwsen-de Boer, Tiny G J, Meijer, Lisethe, Plasschaert, Sabine L A, Scherpen, Frank J, Seitz, Annika, Slagter-Menkema, Lorian, Smit, Marlinde J, van den Berg, Anke, van Kempen, Leon C, van Vugt, Marcel A T M, Warmerdam, Daniël O, Wesseling, Pieter, Zomerman, Walderik W   +24 more
core   +4 more sources