Results 1 to 10 of about 98 (53)

The IL‐18 signaling cascade is implicated in aging, tau pathology and synaptic degeneration [PDF]

Alzheimers Dement
Abstract Background Emerging evidence suggests a bidirectional role of inflammation in Alzheimer's Disease (AD), possibly protecting against amyloid deposition early but exacerbating later tau‐related injury. The NLRP3 inflammasome, a driver of “inflammaging” (chronic low‐grade inflammation increasing with age), is implicated in AD pathogenesis and ...
Sarty I, Picard C, Zetterberg H, Blennow K, Breitner J, Poirier J, PREVENT‐AD Research Group.   +6 more
europepmc   +2 more sources

PSMD‐2: A fully automated marker for longitudinal assessment of cerebrovascular white matter injury [PDF]

Alzheimers Dement
Abstract Background Cerebral small vessel disease (SVD) is highly prevalent in older adults and a key comorbidity in neurodegenerative conditions such as Alzheimer's disease. While conventional MRI markers (e.g. white matter hyperintensities) capture late SVD stages, diffusion MRI metrics are sensitive to early SVD‐related brain changes, making them ...
Dewenter A, Gesierich B, Kopczak A, Oberstein S, Rutten J, Gravesteijn G, Franzmeier N, Markus H, Duering M.   +8 more
europepmc   +3 more sources

Utility of tau biomarkers for detecting clinical outcomes in preclinical Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background While amyloid‐β pathology is a hallmark of preclinical Alzheimer's disease (AD), tau pathology is a key biomarker for early disease‐modifying interventions due to its strong prognostic association with cortical atrophy and cognitive decline.
Labrador‐Espinosa M, Rial A, Franzmeier N, Schöll M.   +3 more
europepmc   +2 more sources

REMOTE‐AD: An Expert Group on Remote Digital Cognitive Assessment and Monitoring for Early Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Background Remote digital cognitive assessments have great potential to address major unmet needs in global healthcare services. Early detection of Alzheimer's disease (AD) and the prediction and monitoring of disease progression represents an ideal use case given the scale of the disease and the limitations of legacy approaches.
Berron D, Cappa S, Clarkson J, Düzel E, Hassenstab J, Jessen F, Jutten R, Kassner A, König A, Libert S, Newton C, Papp K, Polk S, Schicktanz S, Schöll M, Sikkes S, Thyrian J, van der Flier W, Wagner M, Chan D.   +19 more
europepmc   +2 more sources

The DROP‐AD project: AD biomarkers from dry blood spots [PDF]

Alzheimers Dement
Abstract Background In less than a decade, blood‐based biomarkers for Alzheimer's disease (AD) have evolved from a promising research tool to a valuable clinical asset. Increased accessibility to biomarkers such as pTau217 could significantly enhance population screening, epidemiological studies, and the inclusion of underrepresented groups in dementia
Huber H, Brum W, Montoliu‐Gaya L, Dittrich A, Kern S, Sander M, Simonsen A, Corbett A, Fortea J, Palmqvist S, Borroni B, Hansson O, Boada M, Arús X, Blennow K, Zetterberg H, Ashton N.   +16 more
europepmc   +2 more sources

Plasma sphingomyelins are associated with plasma total‐Tau in presymptomatic Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Altered plasma sphingomyelin levels have been associated with Alzheimer's disease (AD), indicating disruptions in lipid metabolism and their potential link with AD pathogenesis. Meanwhile, tau‐related neuronal damage and neurodegeneration result in the release of neuronal tau protein into the bloodstream, reflected predominantly as ...
Sharmin T, Chatterjee P, Doecke J, Ashton N, Sohrabi H, Zetterberg H, Blennow K, Garg M, Martins R.   +8 more
europepmc   +2 more sources

The role of tau and amyloid pathology in neurosensory impairments during preclinical Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Prior cross‐sectional studies in the PREVENT‐AD cohort indicate that increased concentrations of p‐tau181 in cerebrospinal fluid are linked to impairments in odor identification (OI; Lafaille‐Magnan et al., 2017) and central auditory processing (CAP; Tuwaig et al., 2017).
Bowie D, Yakoub Y, Ourry V, Qiu T, Gonzalez‐Ortiz F, Blennow K, Zetterberg H, Poirier J, Villeneuve S.   +8 more
europepmc   +2 more sources

Accelerated rate of plasma p‐Tau217 progression in amyloid‐β APOE ɛ4 carriers [PDF]

Alzheimers Dement
Abstract Background The ɛ4 allele of the apolipoprotein E gene (APOE) increases susceptibility to Alzheimer's disease (AD) and is associated with reduced responsiveness to amyloid‐β (Aβ)‐removing therapies. In the context of AD diagnostics and disease‐modifying treatments, blood biomarkers have emerged as less invasive, accessible tools for monitoring ...
Gonçalves M, Chan T, Macedo A, Rahmouni N, Hosseini S, Hall B, Wang Y, Aumont E, Servaes S, Tissot C, Bezgin G, Arias J, Trudel L, Therriault J, Socualaya K, Stevenson J, Zheng Y, Lussier F, Vitali P, Massarweh G, Soucy J, Benedet A, Zetterberg H, Pascoal T, Woo M, Rosa‐Neto P.   +25 more
europepmc   +2 more sources

Capturing Alzheimer’s Disease Heterogeneity With Spatially Independent Patterns of Amyloid Accumulation [PDF]

Alzheimers Dement
Abstract Background Current Alzheimer's disease (AD) research and clinical trials generally assume a single trajectory of cortical amyloid beta (Aβ) accumulation, but amyloid positron emission tomography (PET) studies suggest multiple trajectories. We aimed to better characterize AD heterogeneity using independent spatial component analysis of amyloid ...
Pieperhoff L, Lorenzini L, Tranfa M, Arunachalam P, Ritchie C, Boada M, Marquié M, van der Flier W, Vandenberghe R, Hanseeuw B, Martínez‐Lage P, Payoux P, Visser P, Schöll M, Frisoni G, Stephens A, Buckley C, Farrar G, Jessen F, Gispert J, Mutsaerts H, Oliveira T, Collij L, Barkhof F, Wink A.   +24 more
europepmc   +3 more sources

Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women [PDF]

Alzheimers Dement
Abstract Background Both nulliparity and multiparity have been linked to an increased risk of dementia. However, evidence is inconclusive and requires further study. To further investigate the link between pregnancy history and cognition, we explored the link between age at first childbirth and cognitive change in cognitively unimpaired (CU) women and ...
Brugulat‐Serrat A, Gallay C, Sánchez‐Benavides G, López‐Martos D, Fernández‐Arcos A, Zetterberg H, Blennow K, Suárez‐Calvet M, Grau‐Rivera O, Gispert J, Sundermann E.   +10 more
europepmc   +2 more sources