Results 11 to 20 of about 2,421 (121)

Amyloid‐induced neuronal hyperactivity and ‐metabolism are associated with faster tau accumulation in Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Background The link between amyloid (Aβ) and tau accumulation in Alzheimer's disease (AD) is still unknown, hindering therapeutic efforts to attenuate the Aβ‐tau axis. Preclinical studies demonstrated that Aβ promotes hyperexcitatory neuronal activity and that tau spreads trans‐synaptically in an activity‐dependent manner.
Roemer‐Cassiano S, Zhang S, Evangelista L, Dehsarvi A, Klonowksi M, Frontzkowski L, Rauchmann B, Steward A, Dewenter A, Biel D, Zhu Z, Hirsch F, Pescoller J, Perneczky R, Malpetti M, Palleis C, Gnörich J, Schöll M, Dichgans M, Jäkel S, Höglinger G, Brendel M, Yeo T, Franzmeier N.   +23 more
europepmc   +2 more sources

CSF proteomics reveals distinct choroid plexus‐related protein signatures in AD, PD and DLB [PDF]

Alzheimers Dement
Abstract Background The choroid plexus (ChP) plays a role in cerebrospinal fluid (CSF) production, protein transport and clearance, and central nervous system homeostasis. Emerging evidence suggests that ChP dysfunction is implicated in the pathogenesis of neurodegenerative diseases.
Delvenne A, Rizzo M, Zhang B, Levit M, Zetterberg H, Blennow K, Kollmorgen G, Krüger R, Fernandes S, Aarsland D, Borejko O, Chokoshvili D, van der Flier W, Lemstra A, Tijms B, Petzold G, Spottke A, Frisoni G, Brockmann K, Gasser T, Fladby T, Wettergreen M, Jessen F, Düzel E, Höglinger G, Chevalier C, Krishnan R, Teunissen C, Vos S, Visser P.   +29 more
europepmc   +2 more sources

Hand grip strength and plasma markers of neurodegeneration among 1026 community‐dwelling older Nigerian adults: Insights from the VALIANT Study [PDF]

Alzheimers Dement
Abstract Background Plasma biomarkers as well as non‐invasive measures of frailty are increasingly employed to aid population‐wide cognitive screening, phenotyping and preclinical diagnosis. Hand grip strength (HGS), a measure of physical and cardiometabolic health, is indicative of early cognitive decline but its relationship with plasma biomarkers of
Olalusi O, Akinyemi T, Benedet A, Ogunde G, Yaria J, Cadmus E, Popoola F, Ogunronbi M, Olujobi D, Famuyiwa O, Akinyemi J, Owolabi M, Romero‐Ortuno R, Udeh‐Momoh C, Ogunniyi A, Pericak‐Vance M, Kalaria R, Lawlor B, Zetterberg H, Akinyemi R.   +19 more
europepmc   +2 more sources

Clinical application and reporting of neurofilament quantification in neuropsychiatric disorders: an international overview [PDF]

Alzheimers Dement
Abstract Background The quantification of Neurofilament Light chain (NfL) in blood and cerebrospinal fluid (CSF) has proven valuable for diagnosing and prognosing various neurological disorders, including Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, parkinsonism, multiple sclerosis, and ischemic damage. However, there is
Delaby C, Ladang A, Yriarte J, Zecca C, Logroscino G, Koertvelyessy P, Tumani H, Parchi P, Quadrio I, Hart M, Olsen D, Alcolea D, Blennow K, Fortea J, Lleó A, Algeciras‐Schimnich A, Ayrignac X, Bedel A, Santos G, Borelli W, Amar E, Baldeiras I, Bigot‐Corbel E, Bjerke M, Perez M, Casoli T, Chabrashvili T, Chapman M, Cusato J, Dursun E, Fourier A, Galimberti D, Gezen‐Ak D, Gordon B, Gouju J, de las Heras Florez S, Sánchez J, Herwerth M, Imperiale D, Kaczorowski F, Kasuga K, Keshavan A, Khalil M, Kuhle J, Leithner C, Lewczuk P, Letournel F, Tsolaki M, Giuffrè G, Blanc M, Mroszko B, Rodríguez‐Álvarez J, Musso G, Kulczynska‐Przybik A, Nogueira L, Paquet C, Baiardi S, Gaetani L, Parnetti L, Garay R, Poesen K, Quillard‐Muraine M, Borja E, Schraen‐Maschke S, Terracciano D, Bachhuber F, Halbgebauer S, Tzartos S, Tzartos J, Unterwalder N, Vermunt L, Wellington C, Zetterberg H, Teunissen C, Lehmann S.   +74 more
europepmc   +2 more sources

The effect of a single visit to a health coach on perceived health in 50-year old residents in a high-income country – a randomised controlled trial

Scandinavian Journal of Primary Health Care, 2022
Objective To evaluate the one-year-effect of a single visit to a health coach on perceived health and exercise level in 50-year-old citizens.Design One factor design randomised controlled trial.Setting Participants were randomly selected from the Swedish
Sofia Ryd, Gerth Persson, Ronny Kent Gunnarsson   +2 more
doaj   +1 more source

Några bärare av tillnamn i Kållands härad på 1500- och 1600-talen

Släkthistoriska Studier
Föreliggande artikel redovisar resultat från en undersökning av personer som bär tillnamn i Kållands härad, nuvarande Västra Götalands län, på 1500- och 1600-talen.
Susanne Gustafsson
doaj   +1 more source

Åtta generationer kvinnor med mitokondrie-DNA haplogrupp V1a7a i Hjärtums socken

Släkthistoriska Studier
Föreliggande artikel redovisar resultatet från en kartläggning av min morfars mor Manda Josefina Gustavsdotters möderneanor. Hon var född 1873 i Hjärtums socken, nuvarande Västra Götalands län.
Susanne Gustafsson
doaj   +1 more source

Governing Within the Constraints of Carbon Budgets: Regional Insights From Sweden

Environmental Policy and Governance, EarlyView.
ABSTRACT Staying within the limits of a rapidly shrinking global carbon budget while avoiding dependency on negative emissions technologies and carbon dioxide removal remains a significant challenge in a multi‐level governance system, where resources and responsibilities are dispersed among different actors.
Paula Lenninger, Magdalena Kuchler
wiley   +1 more source

Efterlevnad av beslut om djurförbud hos hållare av sällskapsdjur och lantbruksdjur i Västra Götalands län [PDF]

, 2013
Denna studie riktar sig främst till länsstyrelsen i Västra Götalands län, som var frågeställare, men också till de andra länsstyrelserna i landet. Syftet var att undersöka hur de personer som på något sätt orsakat lidande hos djur och därför blivit ...
Ringström, Anna
core   +1 more source

Palaeowinds and depositional conditions from Holocene loess in Sweden and Finland

Boreas, EarlyView.
The nature of deglacial and Holocene wind regimes in Fennoscandia is debated, as is the degree to which wind‐blown loess deposits exist in the region. Loess deposits in Fennoscandia are often relatively thin, discontinuous and less well‐sorted than typical loess, and questions remain over the degree of their post‐depositional reworking and the impact ...
Calum J. Edward, Thomas Stevens, Anu Kaakinen, Jukka‐Pekka Palmu, Juha‐Pekka Lunkka, Ramona Schneider, Bjarne Almqvist   +6 more
wiley   +1 more source