Results 11 to 20 of about 40,367 (79)

PSMD‐2: A fully automated marker for longitudinal assessment of cerebrovascular white matter injury [PDF]

Alzheimers Dement
Abstract Background Cerebral small vessel disease (SVD) is highly prevalent in older adults and a key comorbidity in neurodegenerative conditions such as Alzheimer's disease. While conventional MRI markers (e.g. white matter hyperintensities) capture late SVD stages, diffusion MRI metrics are sensitive to early SVD‐related brain changes, making them ...
Dewenter A, Gesierich B, Kopczak A, Oberstein S, Rutten J, Gravesteijn G, Franzmeier N, Markus H, Duering M.   +8 more
europepmc   +3 more sources

The DROP‐AD project: AD biomarkers from dry blood spots [PDF]

Alzheimers Dement
Abstract Background In less than a decade, blood‐based biomarkers for Alzheimer's disease (AD) have evolved from a promising research tool to a valuable clinical asset. Increased accessibility to biomarkers such as pTau217 could significantly enhance population screening, epidemiological studies, and the inclusion of underrepresented groups in dementia
Huber H, Brum W, Montoliu‐Gaya L, Dittrich A, Kern S, Sander M, Simonsen A, Corbett A, Fortea J, Palmqvist S, Borroni B, Hansson O, Boada M, Arús X, Blennow K, Zetterberg H, Ashton N.   +16 more
europepmc   +2 more sources

Plasma sphingomyelins are associated with plasma total‐Tau in presymptomatic Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Altered plasma sphingomyelin levels have been associated with Alzheimer's disease (AD), indicating disruptions in lipid metabolism and their potential link with AD pathogenesis. Meanwhile, tau‐related neuronal damage and neurodegeneration result in the release of neuronal tau protein into the bloodstream, reflected predominantly as ...
Sharmin T, Chatterjee P, Doecke J, Ashton N, Sohrabi H, Zetterberg H, Blennow K, Garg M, Martins R.   +8 more
europepmc   +2 more sources

Capturing Alzheimer’s Disease Heterogeneity With Spatially Independent Patterns of Amyloid Accumulation [PDF]

Alzheimers Dement
Abstract Background Current Alzheimer's disease (AD) research and clinical trials generally assume a single trajectory of cortical amyloid beta (Aβ) accumulation, but amyloid positron emission tomography (PET) studies suggest multiple trajectories. We aimed to better characterize AD heterogeneity using independent spatial component analysis of amyloid ...
Pieperhoff L, Lorenzini L, Tranfa M, Arunachalam P, Ritchie C, Boada M, Marquié M, van der Flier W, Vandenberghe R, Hanseeuw B, Martínez‐Lage P, Payoux P, Visser P, Schöll M, Frisoni G, Stephens A, Buckley C, Farrar G, Jessen F, Gispert J, Mutsaerts H, Oliveira T, Collij L, Barkhof F, Wink A.   +24 more
europepmc   +3 more sources

Accelerated rate of plasma p‐Tau217 progression in amyloid‐β APOE ɛ4 carriers [PDF]

Alzheimers Dement
Abstract Background The ɛ4 allele of the apolipoprotein E gene (APOE) increases susceptibility to Alzheimer's disease (AD) and is associated with reduced responsiveness to amyloid‐β (Aβ)‐removing therapies. In the context of AD diagnostics and disease‐modifying treatments, blood biomarkers have emerged as less invasive, accessible tools for monitoring ...
Gonçalves M, Chan T, Macedo A, Rahmouni N, Hosseini S, Hall B, Wang Y, Aumont E, Servaes S, Tissot C, Bezgin G, Arias J, Trudel L, Therriault J, Socualaya K, Stevenson J, Zheng Y, Lussier F, Vitali P, Massarweh G, Soucy J, Benedet A, Zetterberg H, Pascoal T, Woo M, Rosa‐Neto P.   +25 more
europepmc   +2 more sources

Sex Differences in Health‐Related Quality of Life in Patients With Head and Neck Cancer—A Prospective Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To analyse sex differences in health‐related quality of life (HRQL) before, during and up to 3 months posttreatment of head and neck cancer, and to examine the importance of salivary secretion rate for HRQL posttreatment. Methods Patients were recruited before starting curative oncologic treatment.
Niklas Bohm, Charlott Karlsson, Caterina Finizia, Jessica Skoogh Andersson, Annica Almståhl   +4 more
wiley   +1 more source

The role of tau and amyloid pathology in neurosensory impairments during preclinical Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Prior cross‐sectional studies in the PREVENT‐AD cohort indicate that increased concentrations of p‐tau181 in cerebrospinal fluid are linked to impairments in odor identification (OI; Lafaille‐Magnan et al., 2017) and central auditory processing (CAP; Tuwaig et al., 2017).
Bowie D, Yakoub Y, Ourry V, Qiu T, Gonzalez‐Ortiz F, Blennow K, Zetterberg H, Poirier J, Villeneuve S.   +8 more
europepmc   +2 more sources

Comparison of software vs. cognitive‐based fusion‐targeted biopsies for prostate cancer diagnosis

BJUI Compass, Volume 7, Issue 7, July 2026.
Abstract Objectives This study aimed to compare the effectiveness of software‐based fusion‐targeted biopsies (STBx) versus cognitive fusion‐targeted biopsies (CogTBx) in detecting prostate cancer (PCa) and clinically significant PCa. Materials and methods Men aged 30–85 were included in a target trial emulation if they had undergone a STBx or CogTBx of
Marcus Westerberg, Rolf Gedeborg, Hans Garmo, Fredrik Jäderling, Pär Stattin, David Robinson   +5 more
wiley   +1 more source

Palaeowinds and depositional conditions from Holocene loess in Sweden and Finland

Boreas, Volume 55, Issue 3, Page 808-834, July 2026.
The nature of deglacial and Holocene wind regimes in Fennoscandia is debated, as is the degree to which wind‐blown loess deposits exist in the region. Loess deposits in Fennoscandia are often relatively thin, discontinuous and less well‐sorted than typical loess, and questions remain over the degree of their post‐depositional reworking and the impact ...
Calum J. Edward, Thomas Stevens, Anu Kaakinen, Jukka‐Pekka Palmu, Juha‐Pekka Lunkka, Ramona Schneider, Bjarne Almqvist   +6 more
wiley   +1 more source

Governing Within the Constraints of Carbon Budgets: Regional Insights From Sweden

Environmental Policy and Governance, Volume 36, Issue 3, Page 701-714, June 2026.
ABSTRACT Staying within the limits of a rapidly shrinking global carbon budget while avoiding dependency on negative emissions technologies and carbon dioxide removal remains a significant challenge in a multi‐level governance system, where resources and responsibilities are dispersed among different actors.
Paula Lenninger, Magdalena Kuchler
wiley   +1 more source