Results 171 to 180 of about 298,099 (222)

Effects of 14 days of head‐down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults

Experimental Physiology, EarlyView.
Abstract Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head‐down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure in older adults. Twenty‐two healthy older adults (55–65 years) completed the HDBR protocol.
Guy Hajj‐Boutros, Andréa Faust, Carmelo Mastrandrea, Vita Sonjak, Dounia Rouabhia, Gustavo Duque, Richard Kremer, Stéphanie Chevalier, Julie Lacombe, Mathieu Ferron, Tyler A. Churchward‐Venne, José A. Morais   +11 more
wiley   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 334-344, August 2026.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Highly effective anti‐obesity medications (AOMs) induce substantial weight loss and have renewed debate on appropriate treatment targets. Weight loss comprises reductions in fat mass (FM) and fat‐free mass (FFM), with skeletal muscle (SM) as the major component of FFM.
Anja Bosy‐Westphal, Janna Enderle, Kristina Norman, Manfred J. Müller   +3 more
wiley   +1 more source

Immune Effector Cell‐Associated Hematotoxicity With Secondary Myelofibrosis Following Idecabtagene‐Vicleucel for Multiple Myeloma, Comprehensively Treated With Autologous Hematopoietic Stem Cell Boosting

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Pancytopenia accompanied by chimeric antigen receptor T cell (CAR‐T) therapy is termed immune effector cell‐associated hematopoietic toxicity (ICAHT), which is often sustained and refractory to supportive care. We report a case of a 52‐year‐old man with multiple myeloma who developed severe ICAHT with secondary myelofibrosis (sMF) after ...
Keishi Ogura, Takahiro Fujino, Takahisa Nakamura, Akihiro Miyashita, Akio Onishi, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Shinichi Fuchida, Junya Kuroda   +9 more
wiley   +1 more source

Newly identified intervertebral fat pad degenerates after intervertebral disc injury in a rat model of degeneration

Journal of Anatomy, Volume 249, Issue 2, Page 435-444, August 2026.
This study characterizes a newly‐described intervertebral fat pad (IVFP) anterior to rat IVDs, with evidence for its existence in mice and human IVDs as well. In rats, the IVFP gradually degenerated following IVD injury with changes in adipocyte size and fibrous tissue infiltration, suggesting it could play a functional role in IVD health and ...
Niklas H. Koehne, Irina Heggli, Agnieszka A. Karol, Alon Lai, Svenja Illien‐Jünger, Andrew C. Hecht, Nilsson Holguin, James C. Iatridis   +7 more
wiley   +1 more source

Cystitis in guinea pigs (Cavia porcellus): Clinical findings and treatment outcomes

Veterinary Record, Volume 199, Issue 1, Page e30-e38, 4/11 July 2026.
Abstract Background This retrospective study examined the incidence, diagnostic methods, bacterial isolates, treatments and outcomes associated with cystitis in guinea pigs presented at a single clinic between 2009 and 2022. Methods The clinic's medical records database was reviewed using easyvet software to identify cases eligible for inclusion in the
Anika Mische, Kerstin Müller
wiley   +1 more source

Entering a new era for exercise countermeasures in human spaceflight

Experimental Physiology, EarlyView.
Enrico De Martino, Patrick Swain, Kirsty Lindsay, Claire Bruce‐Martin, Ewoud Jacobs, Bradley Barbour, Chris Buckley, Adam C. McDonnell, Nick Caplan, Luke Hughes   +9 more
wiley   +1 more source

Integration of sarcopenia screening into radiotherapy planning: Validation of a time‐efficient SMI measurement method using MIM software in prostate cancer

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract Background Sarcopenia (SP) affects 43.8% of men with prostate cancer (PCa), correlating with higher all‐cause mortality and reduced quality of life. Systematic SP screening could reduce treatment complications and improve prognosis. Although several validated software tools exist for CT‐based skeletal muscle assessment, their implementation in
Pauline De Bruyn, Nicolas Coquelet, Paulo Ferreira, Madeline Michel, Thomas Descamps, Robbe Van den Begin, Dirk Van Gestel, Jean‐Charles Preiser   +7 more
wiley   +1 more source