Results 31 to 40 of about 296,682 (195)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2013/2014 [PDF]

, 2014
Na época de vigilância 2013/2014 a atividade gripal foi moderada com taxa de incidência máxima de 88,3 casos de SG por 100 000 habitantes na semana 4/2013.
Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Nunes, Baltazar, Pechirra, Pedro   +4 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export

Cell Reports, 2019
Summary: Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA.
Weinan Zheng, Wenhui Fan, Shuang Zhang, Pengtao Jiao, Yingli Shang, Liang Cui, Madina Mahesutihan, Jing Li, Dayan Wang, George Fu Gao, Lei Sun, Wenjun Liu   +11 more
doaj   +1 more source

Analysis of influenza surveillance in Dehong Prefecture， Yunnan Province from 2016 to 2020

Shanghai yufang yixue, 2022
ObjectiveTo perform the analysis of influenza surveillance in Dehong from 2016 to 2020 and determine the epidemic situation of influenza and prevalent virus strains， so as to provide evidence for local influenza prevention and control.MethodsThe ...
YANG Shanrui, GUAN Guoping, KANG Hongjun, YANG Kang, LUO Dingfu   +4 more
doaj   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2012/2013 [PDF]

, 2013
Com o presente relatório, o Instituto Nacional de Saúde Doutor Ricardo Jorge, I.P., pretende sintetizar e divulgar os resultados obtidos pelo Programa Nacional de Vigilância da Gripe (PNVG) durante a época de 2012/2013, em Portugal.
Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Nunes, Baltazar, Pechirra, Pedro   +4 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Influenza B Virus: Some Features of Clinical Findings and Etiotropic Treatment

Журнал инфектологии, 2014
Since January 1997 till March 2009 492 patients with a confirmed diagnosis of influenza A virus and influenza B virus underwent work-up in Military Medical Academy.
O. V. Maltsev, I. S. Grishin, E. V. Peredelsky, N. I. Lvov, K. V. Zhdanov   +4 more
doaj   +1 more source

Influenza season in Portugal (2015/2016): preliminary data [PDF]

, 2016
Este estudo pretende divulgar a análise preliminar dos dados da atividade gripal em Portugal na época de 2015/2016 (setembro de 2015 a junho de 2016).
Costa, Inês, Cristóvão, Paula, Guiomar, Raquel, Machado, Ausenda, Nunes, Baltazar, Patrícia, Conde, Pechirra, Pedro, Rodrigues, Ana Paula   +7 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source