Results 41 to 50 of about 298,714 (268)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2016/2017 [PDF]

, 2017
Ficheiro atualizado em: 18/5/2018 (figuras 21 e 22)O Programa Nacional de Vigilância da Gripe assegura a vigilância epidemiológica da gripe em Portugal, integrando as componentes de vigilância clínica e laboratorial.
Conde, Patrícia, Costa, Inês, Cristóvão, Paula, Guiomar, Raquel, Kislaya, Irina, Nunes, Baltazar, Pechirra, Pedro, Rodrigues, Ana Paula, Silva, Susana Pereira   +8 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Linking influenza virus tissue tropism to population-level reproductive fitness.

PLoS ONE, 2012
Influenza virus tissue tropism defines the host cells and tissues that support viral replication and contributes to determining which regions of the respiratory tract are infected in humans. The location of influenza virus infection along the respiratory
Leslie A Reperant, Thijs Kuiken, Bryan T Grenfell, Albert D M E Osterhaus, Andrew P Dobson   +4 more
doaj   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2017/2018 [PDF]

, 2018
A vigilância da gripe em Portugal através do Programa Nacional de Vigilância da Gripe permite monitorizar, descrever a atividade gripal, detetar e identificar os vírus da gripe em circulação. O programa integra as componentes de vigilância clínica e
Conde, Patrícia, Costa, Inês, Cristóvão, Paula, Guiomar, Raquel, Machado, Ausenda, Pechirra, Pedro, Rodrigues, Ana Paula, Silva, Susana, Torres, Ana Rita   +8 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

IDENTIFIKASI MOLEKULER VIRUS SUBTIPE H3 DAN H10 PADA UNGGAS

Jurnal Kedokteran Hewan, 2014
Penelitian ini bertujuan mengidentifikasi molekuler virus-virus influenza yang tidak dapat diidentifikasi dengan primer H5N1 sehingga perlu dilakukan identifikasi lanjutan dengan primer virus influenza lainnya untuk mengetahui jenis subtipe virus ...
Indi Dharmayanti, Risa Indriani
doaj   +1 more source

MicroRNA expression profile of mouse lung infected with 2009 pandemic H1N1 influenza virus. [PDF]

PLoS ONE, 2013
MicroRNAs have been implicated in the regulation of gene expression of various biological processes in a post-transcriptional manner under physiological and pathological conditions including host responses to viral infections.
Zhihao Wu, Rongzhang Hao, Peng Li, Xiaoai Zhang, Nan Liu, Shaofu Qiu, Ligui Wang, Yong Wang, Wenzhong Xue, Kun Liu, Guang Yang, Jiajun Cui, Chuanfu Zhang, Hongbin Song   +13 more
doaj   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2013/2014 [PDF]

, 2014
Na época de vigilância 2013/2014 a atividade gripal foi moderada com taxa de incidência máxima de 88,3 casos de SG por 100 000 habitantes na semana 4/2013.
Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Nunes, Baltazar, Pechirra, Pedro   +4 more
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source