Results 31 to 40 of about 298,714 (268)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2012/2013 [PDF]

, 2013
Com o presente relatório, o Instituto Nacional de Saúde Doutor Ricardo Jorge, I.P., pretende sintetizar e divulgar os resultados obtidos pelo Programa Nacional de Vigilância da Gripe (PNVG) durante a época de 2012/2013, em Portugal.
Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Nunes, Baltazar, Pechirra, Pedro   +4 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export

Cell Reports, 2019
Summary: Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA.
Weinan Zheng, Wenhui Fan, Shuang Zhang, Pengtao Jiao, Yingli Shang, Liang Cui, Madina Mahesutihan, Jing Li, Dayan Wang, George Fu Gao, Lei Sun, Wenjun Liu   +11 more
doaj   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2010/2011 [PDF]

, 2012
A época de vigilância da gripe de 2010/2011 caracteriza-se por ser a época posterior à primeira pandemia do século XXI, que esteve associada à circulação de um novo subtipo de vírus influenza, o vírus pandémico A(H1N1)pdm09.
Conde, Patrícia, Gonçalves, Paulo, Guiomar, Raquel, Nunes, Baltazar, Pechirra, Pedro   +4 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Influenza B Virus: Some Features of Clinical Findings and Etiotropic Treatment

Журнал инфектологии, 2014
Since January 1997 till March 2009 492 patients with a confirmed diagnosis of influenza A virus and influenza B virus underwent work-up in Military Medical Academy.
O. V. Maltsev, I. S. Grishin, E. V. Peredelsky, N. I. Lvov, K. V. Zhdanov   +4 more
doaj   +1 more source

Efetividade da vacina antigripal na época 2010-2011 em Portugal: resultados do projeto EuroEVA [PDF]

, 2012
Objetivos: O estudo EuroEVA (Efetividade da vacina antrigripal na Europa) teve como objetivos estimar a efetividade da vacina antigripal sazonal 2010-2011 na população geral e nos indivíduos com 65 ou mais anos de idade.
Batista, Inês, Conde, Patrícia, Falcão, Isabel, Gonçalves, Paulo, Guiomar, Raquel, Machado, Ausenda, Marinho Falcão, José, Nunes, Baltazar, Pechirra, Pedro   +8 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Vigilância Virológica da Gripe em Portugal no Inverno 2012/2013 [PDF]

, 2013
Na época de vigilância 2012/2013, o período epidémico foi tardio e de duração semelhante à época anterior. Durante a época de gripe de 2012/2013, verificou-se a co-circulação dos três vírus influenza sazonais com maior destaque para a circulação do ...
Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Nunes, Baltazar, Pechirra, Pedro   +4 more
core