Results 131 to 140 of about 64,869 (199)

Auto‐inducible expression of chimeric antigen receptor T cells using the NR4A1 promoter

Immunology &Cell Biology, EarlyView.
The NR4A1 promoter is a compact auto‐inducible promoter to drive CAR expression in T cells. Compared with EF1α, or existing synthetic antigen‐inducible promoters, NR4A1 is more compact and ensures that resting CAR T cells express reduced baseline CAR. NR4A1 allows rapid induction upon antigen encounter with reduced T‐cell exhaustion.
Samuel WJ Smith‐Bell, Joshua C Halpin, Phillip K Darcy, Thiloma Liyanage, Lachlan J Dobson, Alexander D McLellan   +5 more
wiley   +1 more source

Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy.

JAMA Neurol
Möhn N, Grote-Levi L, Bonifacius A, Tischer-Zimmermann S, Nay S, Jendretzky KF, Sassmann ML, Karacondi K, Zent M, Konen FF, Sühs KW, Meuth SG, Pawlitzki M, Warnke C, Ayzenberg I, Schneider R, Helmchen C, Brüggemann N, Klebe S, Hildner M, Grefkes C, Nitsch L, Hühnchen P, Böltz S, Alt L, Tumani H, Kleinschnitz C, Pul R, Grauer O, Clifford D, Gnanapavan S, Wicklein R, Perpoint T, Beudel M, Del Bello A, Rauer S, Wiendl H, Jelcic I, Gasnault J, Cimini E, Antinori A, Pinnetti C, Pourcher V, Weiss N, Lambert N, Maecker-Kolhoff B, Höglinger GU, Zahraeifard S, Cortese I, Eiz-Vesper B, Martin-Blondel G, Skripuletz T, Immunotherapy for PML Study Group.   +52 more
europepmc   +1 more source

Progressive Multifocal Leukoencephalopathy in Patients with HIV-Case Series from Northeastern Romania. [PDF]

J Clin Med
Loghin II, Dabija MG, Tănase NV, Rusu ȘA, Cecan I, Dorobăț VD, Dorobăţ CM, Eva L.   +7 more
europepmc   +1 more source

Deployment of Perioperative Nurses From Their Clinical Specialty During the COVID‐19 Pandemic: An Integrative Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To identify the available records surrounding the deployment of perioperative nurses into differing clinical settings during the COVID‐19 pandemic. Design Integrative review methodology. Methods Quality appraisal of each record was conducted using a modified Critical Appraisal Skills Programme checklist.
Jennifer Crump, Debra Jackson, Maricris Algoso, Kath Peters   +3 more
wiley   +1 more source

Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Poultry Farm Workers, Washington, USA, 2024. [PDF]

Emerg Infect Dis
Hatta Y, De La Cruz JA, Murray T, Hiatt B, Jang Y, Frederick JC, Lacek KA, DaSilva JC, Cui D, Carney P, Liddell J, Radford KW, Burnett N, Schatzman S, Trinh P, Unutzer A, Pusch EA, Johnson M, Nguyen HT, Rambo-Martin BL, Gubareva L, Stevens J, Davis CT, Kirby MK, Black A, Di H.   +25 more
europepmc   +1 more source

French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025

Journal of the European Academy of Dermatology and Venereology, EarlyView.
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault, Emilie Brenaut, Marie‐Emeline Marniquet, Carla Berthault, Lea Canoen, Clarisse Marcombes, Audrey Melin, Raphaël Ouakrat, Julie Charles, Stephane Mouret, Olivier Potie, Laetitia Penso, Laura Pina Vegas, Guillaume Larid, Marine Roux, Colombe Bougeard, Sandy Sylvain, Clara Labonne, Tania Randriamiarana, Da Hee Pitaud, Floriane Etheve, Jeremy Gottlieb, Laurie Gouillon, Marine Chastagner, Emilie Sbidian, Hélène Aubert, on behalf of the Psoriasis Research Group of the French Society of Dermatology (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), Hélène Aubert, Marie Masson Regnault, Emilie Brenaut, Emilie Sbidian, Laura Pina Vegas, Laetitia Penso, Jeremy Gottlieb, Marine Roux, Clara Labonne, Tania Randriamiarana, Floriane Etheve, Da Hee Pitaud, Marie‐Emeline Marniquet, Carla Berthault, Clarisse Marcombes, Audrey Melin, Colombe Bougeard, Julie Charles, Olivier Potie, Léa Canoen, Laurie Gouillon, Marine Chastagner, Sandy Sylvain, Guillaume Larid, Raphaël Ouakrat   +51 more
wiley   +1 more source

A leucine‐rich‐repeat receptor‐like kinase SERL1 phosphorylates and stabilizes OsALDH2B1 to promote alkaline tolerance and grain size in rice

Journal of Integrative Plant Biology, EarlyView.
The rice aldehyde dehydrogenase OsALDH2B1 enhances grain size and tolerance to alkaline soil by repressing GRAIN SIZE 3 and activating catalases. SERL1‐mediated phosphorylation stabilizes OsALDH2B1 under stress, establishing a signaling axis that overcomes growth‐defense trade‐offs and provides a direct target for breeding high‐yield, alkaline ...
Zemin Ma, Xuanlin Gao, Shuaizu An, Mengyuan Chen, Biaoming Zhang, Lei Zhou, Shengyuan Sun, Ming Li, Feng Yu, Shiyou Lü, Zhaohui Chu, Aiqing You, Yinggen Ke, Pingfang Yang   +13 more
wiley   +1 more source

Causal effects of antibody-mediated immune responses on allergic diseases: A bidirectional Mendelian randomization study. [PDF]

Medicine (Baltimore)
Leng L, Xu T, Tang Q, Li Y, Li X.
europepmc   +1 more source

The Number of Newly Dispensed Hypnotic Drugs During the First COVID‐19 Lockdown Period in The Netherlands

Journal of Sleep Research, EarlyView.
ABSTRACT The 2019 coronavirus (COVID‐19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first‐time dispensed hypnotic drugs during the first COVID‐19 lockdown in the Netherlands, using data from the Dutch ...
Dana M. Dijkgraaf, Pantea Kiani, Maureen N. Zijlstra, Pauline A. Hendriksen, Johan Garssen, Joris C. Verster   +5 more
wiley   +1 more source

Mosquito and arbovirus surveillance in wetlands of South‐East England: Comparison of two adult mosquito traps, use of a novel trap with FTA™ cards and arbovirus testing

Medical and Veterinary Entomology, EarlyView.
Trap performance: Mosquito Magnet® captured significantly more mosquitoes overall, while BG‐Sentinel showed greater species evenness and was more effective for Culex pipiens s.l. and broader species representation. Spatial variation: Mosquito abundance and species composition varied significantly between wetlands, highlighting the importance of site ...
Alexander G. C. Vaux, Harrison Hardy, Lucy Crossley, Colin J. Johnston, Anthony J. Abbott, Stephen Findlay‐Wilson, Amanda Callaghan, Jolyon M. Medlock   +7 more
wiley   +1 more source