Results 91 to 100 of about 9,362,172 (272)

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

eLife, 2017
Hypoxia Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFα subunit, facilitating its proteasome-mediated degradation.
Anna L Miles, Stephen P Burr, Guinevere L Grice, James A Nathan   +3 more
doaj   +1 more source

Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy [PDF]

, 2016
Autophagy is an evolutionarily conserved catabolic process by which cells degrade intracellular proteins and organelles in the lysosomes. Canonical autophagy requires all autophagy proteins (ATGs), whereas noncanonical autophagy is activated by diverse ...
Cai, Xinran, Chen, Xiaoyun, Fu, Yuanyuan, Gao, Ying, Hong, Liang, Huang, Heqing, Li, Min, Li, Sitong, Lin, Yujie, Liu, Peiqing, Liu, Xingguo, Liu, Yajun, Vogt, Andreas, Wen, Weijie, Yang, Zuolong, Yin, Xiao-Ming   +15 more
core   +1 more source

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

Nature Communications, 2017
Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Maria B Bagh, Shiyong Peng, G. Chandra, Zhongjian Zhang, S. Singh, N. Pattabiraman, Aiyi Liu, A. Mukherjee   +7 more
semanticscholar   +1 more source

Rotating with the brakes on and other unresolved features of the vacuolar ATPase [PDF]

, 2016
The rotary ATPase family is comprised of the ATP synthase (F-ATPase), vacuolar ATPase (V-ATPase) and acrahael ATPase (A-ATPase). These either predominantly utilise a proton gradient for ATP synthesis or use ATP to produce a proton gradient, driving ...
Abrahams, Allegretti, Arai, Armbrüster, Benlekbir, Blair, Boyer, Bueler, Compton, Diab, Dow, Fais, Forgac, Hildenbrand, Hinton, Hong-Hermesdorf, Huss, Iino, Jansen, Jefferies, Kane, Ludwig, Makyio, Marshansky, Merzendorfer, Michael A. Harrison, Morales-Rios, Muench, Muench, Muench, Murata, Perez-Sayans, Rawson, Richardson, Sambade, Sennoune, Shaun Rawson, Smith, Stephen P. Muench, Stewart, Stransky, Sumner, Tabke, Wilkens, Zhao, Zhou   +45 more
core   +1 more source

Regulation of Luminal Acidification by the V-ATPase

Physiology, 2013
Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disorders, including renal distal tubular acidosis and male infertility.
Sylvie Breton, Dennis Brown
openaire   +4 more sources

Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling

Journal of Biological Chemistry, 2018
The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump involved in many cellular processes. An important mechanism by which V-ATPase activity is controlled is the reversible assembly of its two domains, namely the peripheral V1 domain and the ...
C. McGuire, M. Forgac
semanticscholar   +1 more source

Papillomavirus E5: the smallest oncoprotein with many functions [PDF]

, 2011
Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Borzacchiello, G., Campo, M.S., Corteggio, A., Nasir, L., Paolini, F., Roperto, S., Venuti, A.   +6 more
core   +4 more sources

V-ATPase subunit B plays essential roles in the molting process of the Chinese mitten crab, Eriocheir sinensis

Biology Open, 2020
Vacuolar ATPase (V-ATPase) is a proton pump driven by ATP hydrolysis, and it plays an important role in numerous biological processes, such as protein degradation and synthesis, cell growth, and cell autophagy.
Xin Hou, Xiaowen Chen, He Yang, Wucheng Yue, Jun Wang, Hua Han, Chenghui Wang   +6 more
doaj   +1 more source

V-ATPase-Mediated Granular Acidification Is Regulated by the V-ATPase Accessory Subunit Ac45 in POMC-Producing Cells [PDF]

Molecular Biology of the Cell, 2010
The vacuolar (H+)-ATPase (V-ATPase) is an important proton pump, and multiple critical cell-biological processes depend on the proton gradient provided by the pump. Yet, the mechanism underlying the control of the V-ATPase is still elusive but has been hypothesized to involve an accessory subunit of the pump.
Jansen, E.J.S., Hafmans, T.G.M., Hafmans, T.G.M., Martens, G.J.M.   +3 more
openaire   +5 more sources

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]

, 2015
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng, Guo, Wei, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K, Sun, Xin   +5 more
core   +3 more sources