Results 101 to 110 of about 9,362,172 (272)
Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]
, 2020 Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T +11 more
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Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification
Nature Communications, 2015 The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with ...
Caroline Mauvezin +3 more
semanticscholar +1 more source
Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]
, 2020 Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E. +6 more
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Trends in Genetics, 2000 Vacuolar proton-conducting ATPases (V-ATPases) are key components in the control of pH and ionic homeostasis in eukaryotes. They feature centrally in plant cell biology because, in plants, proton gradients support the bulk of secondary active transport of solutes and ions. However, genetic analysis of V-ATPase function in plants has been lacking.
openaire +3 more sources
NFAT2 in the regulation of CAII and V-ATPase mRNA expression in osteoclast-like cells and intervention study of PEMF [PDF]
, 2016 目的：研究低频脉冲电磁场(PEMF)对去卵巢大鼠核因子κB受体活化因子（RANK）、活化T细胞核因子(NFATc1/NFAT2)、碳酸酐酶II（CAII）、空泡型H+三磷酸腺苷转运酶（V-ATPase）基因表达的影响；研究NFAT2对CAII和V-ATPase基因表达的调控作用。 方法：1.选取48只雌性SD大鼠，分为三组，分别为SHAM（假手术）组、OVX（去卵巢）组、OVX+PEMF组，OVX+PEMF组随机选一半被PEMF干预14天和28天，测雌激素和骨密度。RT-PCR检测NFAT2、RANK ...
傅继凡
core
Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer [PDF]
, 2012 Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic alkalinisation, increased acid
Hernández López, Agustín +3 more
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Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas [PDF]
, 2018 Proteomic analysis was performed to compare the effects of Arsenic (As), seawater acidification (Low pH) and the combination of both stressors (Low pH + As) on Crassostrea angulata and Crassostrea gigas juveniles in the context of global environmental ...
Bebianno, Maria +6 more
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Diagnostic Pathology, 2012 Background ATP-binding cassette sub-family G member 2 (ABCG2) is a protein that in humans is encoded by the ABCG2 gene. ABCG2 participates in efflux of many chemotherapeutic agents.
Huang Lijun +5 more
doaj +1 more source
Inhibitors of V-ATPases: old and new players [PDF]
Journal of Experimental Biology, 2009 SUMMARYV-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a multitude of eukaryotic endomembranes and plasma membranes, they energize many different transport processes. Currently, a handful of specific inhibitors of the V-ATPase are known, which represent valuable tools for ...
Markus Huss, Helmut Wieczorek
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Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment
Scientific Reports, 2018 Secretory lysosomes are required for the specialised functions of various types of differentiated cells. In osteoclasts, the lysosomal proton pump V-ATPase (vacuolar-type ATPase) is targeted to the plasma membrane via secretory lysosomes and subsequently
Naomi Matsumoto +7 more
semanticscholar +1 more source