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Structure and Regulation of the V-ATPases
Journal of Bioenergetics and Biomembranes, 2005The V-ATPases are ATP-dependent proton pumps present in both intracellular compartments and the plasma membrane. They function in such processes as membrane traffic, protein degradation, renal acidification, bone resorption and tumor metastasis. The V-ATPases are composed of a peripheral V(1) domain responsible for ATP hydrolysis and an integral V(0 ...
Takao, Inoue +5 more
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1995
Insects are one of the most successful classes of organism in the world. Their small size, impermeable exocuticle and short generation times have allowed them to adapt to exploit a huge range of ecological niches, many of which place them in conflict with humans.
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Insects are one of the most successful classes of organism in the world. Their small size, impermeable exocuticle and short generation times have allowed them to adapt to exploit a huge range of ecological niches, many of which place them in conflict with humans.
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V-ATPase: a potential pH sensor
Nature Cell Biology, 2006An interaction between V-ATPase, a multi-subunit complex responsible for endosome acidification, and ARNO, the GDP/GTP exchange factor for ARF1 and ARF6, indicates that V-ATPase is the long-sought pH-sensor that regulates trafficking in the endocytic pathway.
Chiara Recchi, Philippe Chavrier
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V-ATPase functions in normal and disease processes
Pflügers Archiv - European Journal of Physiology, 2007Eukaryotic cells have evolved a family of ATP-dependent proton pumps known as the vacuolar (H(+))-ATPases (or V-ATPases) to regulate the pH of intracellular compartments, the extracellular space, and the cytoplasm. V-ATPases present within intracellular compartments are important for such normal cellular processes as receptor-mediated endocytosis and ...
Ayana, Hinton +2 more
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V-ATPase, ScNhx1p and Yeast Vacuole Fusion
Journal of Genetics and Genomics, 2012Membrane fusion is the last step in trafficking pathways during which membrane vesicles fuse with target organelles to deliver cargos. It is a central cellular reaction that plays important roles in signal transduction, protein sorting and subcellular compartmentation.
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Rotation, Structure, and Classification of Prokaryotic V-ATPase
Journal of Bioenergetics and Biomembranes, 2005The prokaryotic V-type ATPase/synthases (prokaryotic V-ATPases) have simpler subunit compositions than eukaryotic V-ATPases, and thus are useful subjects for studying chemical, physical and structural properties of V-ATPase. In this review, we focus on the results of recent studies on the structure/function relationships in the V-ATPase from the ...
Ken, Yokoyama, Hiromi, Imamura
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The V-ATPase inhibitor archazolid
2014Fighting metastasis is a major challenge in cancer therapy and novel therapeutic targets and drugs are highly appreciated. Resistance of invasive cells to anoikis, a particular type of apoptosis induced by loss of cell-extracellular matrix (ECM) contact, is a major prerequisite for their metastatic spread. Inducing anoikis in metastatic cancer cells is
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V-ATPase inhibitor targets Ras-mutant cancers
Nature Reviews Drug Discovery, 2022openaire +2 more sources