Results 211 to 220 of about 7,510,342 (308)

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Outcomes of ACL Reconstruction with Quadriceps Tendon Graft Based on Graft Diameter Relative to Notch Width. [PDF]

Orthop J Sports Med
Dadoo S, Vieider RP, Grandberg C, Drain NP, Steuer F, Mattar LT, Hartline J, Hughes JD, Irrgang JJ, Musahl V.   +9 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Synergistic amelioration of cholestatic liver fibrosis by combined total astragalus saponins and AAV8.<i>Numb</i>-Exon3 through modulation of hepatic progenitor cell differentiation. [PDF]

Front Pharmacol
Zong M, Xu Y, Xing F, Wang D, Zheng X, Zhang S, Zhan J, Chen J, Chen G, Liu W, Liu P, Mu Y.   +11 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis. [PDF]

JCI Insight
Rajeh A, Shahsavari S, Cornman H, Kollhoff A, Gupta A, Szeto MD, Kambala A, Oladipo OO, Parthasarathy V, Deng J, Marani M, Shahsavari S, Yossef SM, Vaddaraju V, Adawi W, Akiska YM, Gage DM, Wheelan S, Pritchard T, Kwatra MM, Semenov YR, Gusev A, Ho WJ, Yegnasubramanian S, Kwatra SG.   +24 more
europepmc   +1 more source

One‐Step Preparation of Lanthanide‐Doped Polyurea Multicolor Microspheres for Versatile Fluorescent Applications

Advanced Science, EarlyView.
Lanthanide‐doped polyurea microspheres are prepared via a facile one‐step precipitation polymerization. They exhibit strong hydrogen‐bonding and coordination interactions with excellent properties, including multicolor emission, high quantum yield (75.3%), remarkable stability, redispersibility, and biocompatibility.
Guiyu Zhang, Xiaoxia Yu, Xinhui Wang, Xiang Zheng Kong, Xiangling Gu, Jitao Liu, Shusheng Li, Xiaoli Zhu, Lianbao Cao, Xubao Jiang   +9 more
wiley   +1 more source

Anatomic Risk Factors Predisposing Female Handball Players to Non-contact Anterior Cruciate Ligament Injury. [PDF]

Cureus
Papadopoulou Z, Vasiliadis AV, Vrampa EM, Galanis N.   +3 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients. [PDF]

Stem Cell Reports
Wang X, Li L, Chen Z, Zeng Y, Shu P, Hou L, Yin B, Liu W, Peng X.   +8 more
europepmc   +1 more source