Results 221 to 230 of about 9,951,210 (253)

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Maternal metabolic stress regulates progeny intestinal stem cell niche signaling through heritable changes in redox metabolites. [PDF]

Nat Commun
Hocaoglu H, Qin S, Eller L, Abu F, Ohlstein B, Wang L, Sieber MH.   +6 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Oncoviruses at the Crossroads of Ageing and Cancer: Molecular Mechanisms and Key Signalling Pathways. [PDF]

Rev Med Virol
Allehyani N, Alissa M, Alghamdi A, Alshehri MA, Abusalim GS, Juraybi TN, Alsuwat MA, Safhi AY.   +7 more
europepmc   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Research Advances in Nanodrugs Targeting Lipid Metabolism Reprogramming for Colorectal Cancer Therapy. [PDF]

Int J Nanomedicine
Tang J, Liu M, Zhang R, Li Q, Wang S, Wang Y.   +5 more
europepmc   +1 more source

Optimal Radial Head Prosthesis Sizing in Elbow Trauma: A Review of Anatomical Principles and Clinical Techniques. [PDF]

JBJS Rev
Alabbasi KK, King GJW.
europepmc   +1 more source

DLL1-mediated ferroptosis resistance via the Notch-Nrf2/GPX4 axis drives cisplatin resistance in ovarian cancer. [PDF]

Cancer Metab
Ye D, Huang G, Yan X, Suntan L, Shen H, Shen J.   +5 more
europepmc   +1 more source

Arthroscopic Dissection and Protection of an Aberrant Suprascapular Nerve During Massive Rotator Cuff Repair. [PDF]

Arthrosc Tech
Khan PS, Meleppuram JJ, Nair AV, Nizar Ahamed H, Nasimudeen N, Radhakrishnan A, Sathyadasan S.   +6 more
europepmc   +1 more source

Hypertrophic Mucoid Degeneration of the Anterior Cruciate Ligament Mimicking a Tear: A Case Report and Diagnostic Pitfall. [PDF]

Cureus
Abdallah AS, Messaoud O, Iraqi Houssaini Z, Jroundi L, El Aoufir O.   +4 more
europepmc   +1 more source