Results 121 to 130 of about 5,753 (291)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

A Brazilian glycoprotein E-negative bovine herpesvirus type 1.2a (BHV-1.2a) mutant is attenuated for cattle and induces protection against wild-type virus challenge [PDF]

The authors previously reported the construction of a glycoprotein E-deleted (gE-) mutant of bovine herpesvirus type 1.2a (BHV-1.2a). This mutant, 265gE-, was designed as a vaccinal strain for differential vaccines, allowing the distinction between ...
Esteves, P.A., Flores, E.F., Franco, A.C., Lima, M., de, Rijsewijk, F.A.M., Roehe, P.M., Spilki, F.R., Weiblen, R.   +7 more
core   +1 more source

Immunological Evaluation of Two Local Isolates of Eimeria tenella Gametocytes against Coccidiosis in Poultry [PDF]

, 2012
Two local isolates of Eimeria tenella gametocytes against coccidiosis were immunologically evaluated in chickens. Cell mediated immune response was detected by modified splenic cell migration inhibition assay (MSCMIA) and data were expressed in terms of ...
Masood Akhtar*, M. Irfan Anwar, Zafar Iqbal, Faqir Muhammad1, Mian Muhammad Awais, Ahsan ul Haq2 and Elzbieta Hiszczynska-Sawicka3
core  

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

STUDYING DEVELOPMENT OF POST-VACCINAL CELLULAR IMMUNITY AGAINST BRUCELLOSIS BY MEANS OF LYMPHOCYTE IN VITRO TESTS USING AN EXPERIMENTAL ANTIGENIC COMPLEX

Медицинская иммунология, 2019
Introduction: regulatory framework and methodological approaches to evaluation of immunological effects of vaccination against brucellosis are not established, and the degree of immunological post-vaccinal rearrangement is not yet developed.
Dmitry Grigorievich Ponomarenko, Kostyuchenko Marina Vladimirovna, Rakitina Ekaterina Lvovna, Logvinenko Olga Vasilievna, Kurcheva Svetlana Aleksandrovna, Berdnikova Tatiana Vasilievna, Rusanova Diana Vladimirovna, Kulichenko Alexander Nikolaevich   +7 more
doaj  

Live vaccine strain recommendations for the human influenza vaccine

, 2020
Up to 5 million annual influenza infections cause substantial morbidity and mortality in seasonal epidemics around the globe. Human influenza A viruses undergo constant genetic and antigenic drift allowing recurrent infections in the human population. To ensure continued protection against influenza infections, the viral strains used for the production
Klingen, Thorsten, Reimering, Susanne, McHardy, Alice C.   +2 more
openaire   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Essai comparatif d'efficacité des deux souches vaccinale T1/44 et T1st contre la préripneumonie contagieuse bovine [PDF]

, 1999
La péripneumonie est une maladie infectieuse qui touche uniquement les bovidés et connaît actuellement une recrudescence en Afrique. Dans le passé de nombreux pays ont pu contrôler la maladie, voire l'éradiquer, grâce à une prophylaxie médicale basée sur
Amara, A., Golsia, R., Hamadou, B., Thiaucourt, François, YaYa, Aboubakar   +4 more
core