The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su +10 more
wiley +1 more source
Factors associated with COVID-19 vaccination schedule completion among adults in high-social-vulnerability neighborhoods in two Brazilian state capitals: A cross-sectional study. [PDF]
Iunes FM +11 more
europepmc +1 more source
Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan +21 more
wiley +1 more source
Prevalence and its associated factors of zero-dose vaccination and barriers among children under the age of 2 years in Southwest Ethiopia: A mixed-method study. [PDF]
Tamirat F, Adimasu Kebede M.
europepmc +1 more source
CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou +5 more
wiley +1 more source
Drivers and barriers to influenza vaccination in the post-COVID-19 era in the Federation of Bosnia and Herzegovina: A qualitative study using focus groups with risk groups and in-depth interviews with physicians. [PDF]
Musa S +4 more
europepmc +1 more source
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Comparative analysis of the impact of chickenpox and herpes zoster vaccination in Belgium under two different exogenous boosting mechanisms. [PDF]
Wambua J +4 more
europepmc +1 more source

