Advanced Science, EarlyView.Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui +19 more
wiley +1 more source
A Reassessment of Serious Adverse Events After Human Papillomavirus Vaccination in the Nagoya Survey in Japan by Using Incidentality Analysis. [PDF]
CureusSuzumura Y.
europepmc +1 more source
EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells
Advanced Science, EarlyView.ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li +15 more
wiley +1 more source
Feature representation in analysing childhood vaccination defaulter risk predictors: A scoping review of studies in low-resource settings. [PDF]
PLOS Digit HealthOdei-Lartey EO +5 more
europepmc +1 more source
Experience with Vaccination Against Influenza in the Spring of 1947
, 1947 Thomas Francis +2 more
openalex +1 more source
Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination
Advanced Science, EarlyView.A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li +6 more
wiley +1 more source
Retrospective Cross-Sectional Study of Occupational Infection Risk With Zoonotic Pathogens in Austrian Veterinary Practitioners in the Year 2022. [PDF]
Vet Med SciSattler T +9 more
europepmc +1 more source
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Infection prevention in patients with hereditary hemorrhagic telangiectasia
Haematologica, 2018 Juan Rodríguez-García +3 more
doaj +1 more source
Advanced Science, EarlyView.Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang +10 more
wiley +1 more source