Results 191 to 200 of about 1,424,765 (382)

J Am Med Dir Assoc [PDF]

BackgroundInstitutionalized adults are at increased risk of morbidity and mortality from influenza and pneumococcal infection. Influenza and pneumococcal vaccination have been shown to be effective in reducing hospitalization and deaths due to pneumonia ...

core  

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Impact of the COVID-19 pandemic on influenza vaccination coverage in Latin America: Southern Cone, Argentina, Chile, and Uruguay

Revista Panamericana de Salud Pública
Objective. Analyze the impact of the COVID-19 pandemic on influenza vaccination coverage in some countries in the Americas. Methods. This descriptive ecological study included Argentina, Chile, and Uruguay and analyzed information on influenza ...
Pablo Bonvehi, Ruby Trejo Varon, Carlos Espinal, Helena Brenes Chacon, Francisco Becerra-Posada   +4 more
doaj   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Influenza vaccination coverage in Japan [PDF]

The Lancet, 2003
Lee, Jung Su, Kawakubo, Kiyoshi
openaire   +2 more sources

COVID-19 cross-sectional study in Maricá, Brazil: The impact of vaccination coverage on viral incidence

, 2022
Thiago Silva Frauches, Carlos Alberto de Senna Costa, Claudia dos Santos Rodrigues, Marcelo Costa Velho Mendes de Azevedo, Michelle de Moraes Ferreira, Hanna Beatriz Vieira da Silva Ramos, Wilson Rodrigues de Souza, Andréa Ribeiro Costa, Adriana Cardoso Camargo, Adriana Halfeld Alonso, Fábio Álvaro dos Santos, Hércules da Silva Oliveira, Janaína Guimarães Coelho, Joyce Florentina da Silva Sobral, Luciane Cardoso dos Santos Rodrigues, Marcio Martins Casaes Ferreira, Patricia Laureano, Raquel Adalgiza da Paz Fernandes, Renata da Silva Santos, Rose Mary Carvalho dos Santos, Sanderson Milagres, Vanessa Cristina Conceição dos Santos, Jussara Teixeira Silva, Tatiana Martins da Silva, Malu Gabriela Costa da Rocha, Andreia Edwirges de São Carlos, Amorim Mourão de Araújo Ramos, Fernanda Martins de Almeida Bastos, Daina Raylle Francisco, Sabrina dos Santos Rosa, Layla Corrêa Linhares, Raíssa Rodrigues Organista, Leandro F.S. Bastos, Maria Magdalena Kelly Pinto, Jean Pablo Lima do Nascimento, João Pedro Moura da Silveira, Mateus Quintanilha dos Santos, Nathaly Santos da Silva, Nayra Cristina dos Santos Ferreira, Rafael Brito Ramirez Reis, Ruan Fonseca de Oliveira, Valdinei de Oliveira Sá, Thyago Ramos de Siqueira Hammes, Juliano de Oliveira Monteiro, Pedro Henrique Cardoso, Mônica Barcellos Arruda, Patricia Alvarez, Richard Araújo Maia, Liane de Jesus Ribeiro, Orlando C. Ferreira, Aline Regina Santos, Alberto Carlos Melo de Almeida, Lauro Garcia, Celso Pansera, Amílcar Tanuri   +54 more
openalex   +1 more source

Estimating the early impact of vaccination against COVID-19 on deaths among elderly people in Brazil: Analyses of routinely-collected data on vaccine coverage and mortality [PDF]

, 2021
César G. Victora, Márcia C. Castro, Susie Gurzenda, Arnaldo Correia de Medeiros, Giovanny Vinícius Araújo de França, Aluísio J. D. Barros   +5 more
openalex   +1 more source