Results 41 to 50 of about 17,678 (247)

Vaccination coverage in children in the period before and during the COVID-19 pandemic in Brazil: a time series analysis and literature review

Jornal de Pediatria, 2023
Objective: To evaluate the behavior of VCR and VCH, per municipality and per vaccines offered at the NVC, to identify priority areas for intervention. Methods: Descriptive study of a time series, using secondary data and accompanied by a narrative review
Carla Magda Allan S. Domingues, Antônia Maria da Silva Teixeira, José Cássio de Moraes   +2 more
doaj   +1 more source

Determinants of parental vaccine hesitancy in Canada: results from the 2017 Childhood National Immunization Coverage Survey

BMC Public Health, 2023
Background In 2019, the World Health Organization (WHO) designated vaccine hesitancy as one of the ten leading threats to global health. Vaccine hesitancy exists when vaccination services are available and accessible, but vaccine uptake is lower than ...
Ruoke Chen, Mireille Guay, Nicolas L. Gilbert, Eve Dubé, Holly O. Witteman, Hina Hakim   +5 more
doaj   +1 more source

Factors influencing influenza, pneumococcal and shingles vaccine uptake and refusal in older adults: a population-based cross-sectional study in England

BMJ Open, 2023
Objectives Uptake of influenza, pneumococcal and shingles vaccines in older adults vary across regions and socioeconomic backgrounds. In this study, we study the coverage and factors associated with vaccination uptake, as well as refusal in the ...
Francesco Zaccardi, Kamlesh Khunti, Carol Coupland, Julia Hippisley-Cox, Simon J Griffin, Pui San Tan, Baiju R Shah, Defne Saatci, Cesar Garriga, Hajira Dambha-Miller, Tom A Ranger, Ashley Kieran Clift, Martina Patone   +12 more
doaj   +1 more source

Parents who refuse or delay HPV vaccine: Differences in vaccination behavior, beliefs, and clinical communication preferences

Human Vaccines & Immunotherapeutics, 2017
Background: We sought to estimate the national prevalence of HPV vaccine refusal and delay in a nationally-representative sample of parents of adolescents.
Melissa B. Gilkey, William A. Calo, Macary W. Marciniak, Noel T. Brewer   +3 more
doaj   +1 more source

Attitudes towards mandatory vaccination and sanctions for vaccination refusal

Vaccine, 2022
Investigating attitudes towards mandatory vaccination and sanctions for vaccination refusal in an area with insufficient vaccination coverage may help health authorities to assess which strategies for increasing vaccination coverage are appropriate. This study examines attitudes to vaccine mandates and asks questions regarding what kinds of sanctions ...
Slotte, Pamela, Soveri, Anna, Karlsson, Linda   +2 more
openaire   +4 more sources

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Repertoires of Vaccine Refusal in Romania

Vaccines, 2020
Repertoires are basic analytic units in discourse analysis and discursive psychology, characterized as repeatable building blocks speakers use for constructing versions of actions. In this study my aim is to analyze public repertoires which are available to parents as discursive resources to substantiate their decision not to vaccinate their children ...
openaire   +3 more sources

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Vaccine hesitancy among healthcare professionals and the general population: Second important step in the fight against COVID-19

Journal of Infection in Developing Countries, 2023
Introduction: This study aims at finding valuable information for predicting vaccination intentions against COVID-19 to guide future interventions to address hesitation.
Salih Metin, Suna Eraybar, Huseyin Aygun, Ferhat Ekinci   +3 more
doaj   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source