Results 101 to 110 of about 1,128,358 (233)
Advanced Synthesis &Catalysis, EarlyView.Abstract Methodology for direct fluoroalkenylation of phenolic OH function was developed using a fluorinated electrophilic reagent derived from HFO1234ze gas. Besides various functionalized phenols, tyrosine and tyrosine‐based peptides were successfully conjugated under the optimized reaction conditions.
Rihárd Sisa +2 more
wiley +1 more source
Mimicking Biochemical Traits with a Synthetic Lipid Nanoparticles SARS‐COV‐2 Model
Advanced Therapeutics, EarlyView.A synthetic virus model developed using lipid nanoparticles, which incorporate encapsulated mRNA and nucleocapsid (N) protein along with surface‐conjugated spike (S) protein, mimics the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), allowing for the advancement of diagnostic product assessment.
Ignasia Handipta Mahardika +7 more
wiley +1 more source
Vaccines: Propaganda and Practice [PDF]
, 2008 Vaccines are a cost effective, time tested means of reducing morbidity and mortality. As more and more new vaccines are introduced and more diseases come under the purview of ‘vaccination net’, the routine immunization program is sidelined.\ud This is ...
Baliga, Shantharam B, Baliga, Shrikala
core +1 more source
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Vaccine Myths: Setting the Record Straight [PDF]
, 2018 Despite their standing as one of the most remarkable public health achievements, vaccines have been surrounded by dangerous myths since the development of the smallpox vaccine in the 18th century.
Boom, Julie A +2 more
core +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
Advanced Theory and Simulations, EarlyView.The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak +2 more
wiley +1 more source
, 2019 Purpose/Background: Since introduction of the human papillomavirus (HPV) vaccine in 2006, national efforts to increase vaccine uptake have been largely successful in urban areas, but less effective in rural settings.
Newcomer, Sophia
core
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Advanced Science, EarlyView.Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou +8 more
wiley +1 more source
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source