Results 231 to 240 of about 886,403 (306)

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Fluorine‐Directed Automated Mannoside Assembly

Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023
Motivated by the importance of fluorination in drug discovery, fluorine‐directed automated glycan assembly (AFGA) is disclosed. This strategy leverages the C(sp3)−F bond at C2 to enable α‐stereocontrolled glycosylation that eliminates the reliance on O‐based directing groups.
Charlotte S. Teschers, Ryan Gilmour
wiley   +1 more source

Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming

Advanced Science, EarlyView.
This study addresses the challenges of synthetic circular RNAimpurities that trigger immune responses and hinder efficacy. Key immunogenic byproducts are identified and develop a multi‐step purification process that produces ultra‐pure circRNA and enhances yields by over 10‐fold.
Ziwei Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Yu, Daming Wang, Yuhong Cao   +7 more
wiley   +1 more source

Antigenicity of β-Propiolactone-Inactivated Virus Vaccines [PDF]

, 1955
Gerald A. LoGrippo, Frank W. Hartman
openalex   +1 more source

Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy

Advanced Science, EarlyView.
Engineered Lactobacillus acidophilus (LH@LA) is developed via in situ polymerization to co‐load lactate oxidase (LOx) and horseradish peroxidase (HRP). This system preserves LA activity, evades macrophage phagocytosis, and synergizes LA metabolism with enzyme cascades to enhance immunity, reduce tumor ATP, suppress PD‐L1 expression and AKT‐mTOR ...
Liuzhou Mao, Bahriman Xarpidin, Rui Shi, Yuting Lin, Haohua Hu, Caisheng Wu, Zheng Luo, Yun‐Long Wu   +7 more
wiley   +1 more source

Dangers Associated with the Use of Living “Attenuated” Typhus Vaccine

, 1946
Joseph F. Sadusk, Hartwig Kuhlenbeck
openalex   +1 more source

EFFECT OF REPEATED FREEZING (–185°C.) AND THAWING ON COLON BACILLI, VIRUS III, VACCINE VIRUS, HERPES VIRUS, BACTERIOPHAGE, COMPLEMENT, AND TRYPSIN [PDF]

, 1927
T. M. Rivers
openalex   +1 more source

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Advanced Science, EarlyView.
LNPsD18, a cationic liposome that enhances antigen‐presenting cell uptake in the spleen and tumor without targeting ligands is developed. Co‐delivering neoantigens and a TLR9 agonist significantly improve DC activation, tumor immunity, and survival in liver and colorectal cancer models, demonstrating the importance of dual‐site APC targeting for cancer
Yu Xu, Bing Wang, Yue Huang, JianPing Liao, Chenyi Wu, Chenxi Zhou, Zishi Kang, Shiyang Jiang, Bing‐Chen Wu, Da Zhang, Ruihua Xu, Xiaolong Liu, Feng Wang   +12 more
wiley   +1 more source

COVID‐19 in the Pacific territories: Isolation, borders and the complexities of governance

Asia &the Pacific Policy Studies, Volume 9, Issue 3, Page 394-407, September 2022., 2022
Abstract Early experience of COVID‐19 in seven Pacific politically dependent territories (Guam, American Samoa, Pitcairn, Tokelau, French Polynesia, Wallis and Futuna, and New Caledonia) emphasises a diversity of contexts, responses, outcomes and possible futures.
John Connell
wiley   +1 more source

Concentration and Purification of Influenza Virus for the Preparation of Vaccines [PDF]

, 1945
A. R. Taylor, D. G. Sharp, I. W. McLean, Dorothy Beard, J. W. Beard   +4 more
openalex   +1 more source