Results 241 to 250 of about 886,403 (306)
Advanced Science, EarlyView.This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang +5 more
wiley +1 more source
BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock +3 more
wiley +1 more source
The use of culture virus in the preparation of foot-and-mouth disease vaccine [PDF]
, 1953 W. M. Henderson, I. A. Galloway
openalex +1 more source
STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy
Advanced Science, EarlyView.STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken +3 more
wiley +1 more source
Advanced Science, EarlyView.This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren +6 more
wiley +1 more source
TYPHOID-PARATYPHOID VACCINATION WITH MIXED VACCINES [PDF]
, 1913 A. Castellani
openalex +1 more source
Bioengineering Platelets Presenting PD‐L1, Galectin‐9 and BTLA to Ameliorate Type 1 Diabetes
Advanced Science, EarlyView.IFN‐γ‐primed platelets enriched with immunosuppressive ligands (PD‐L1, PD‐L2, BTLA, and Gal‐9) are shown to induce T cell exhaustion and apoptosis, preserving β‐cell function and preventing hyperglycemia progression in type 1 diabetes. IFN‐γ platelets also promote Treg expansion, macrophage polarization, and β‐cell proliferation, offering a promising ...
Yumeng Ma +14 more
wiley +1 more source
Case of Inoperable Cancer of the Fauces, the Pharynx, the Tongue, and the Cervical Glands that has shown Marked Amelioration after Treatment for Ten Weeks with a Bacterial Vaccine of Neoformans [PDF]
, 1906 Scanes Spicer, A. E. Wright
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