Results 271 to 280 of about 2,182,415 (399)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Comparison of safety and immunogenicity between Healive®, Havrix® and live attenuated Hepatitis A vaccines in pediatric population: a systematic review with meta-analysis. [PDF]

Ital J Pediatr
Abo Zeid M, Elrosasy A, Farho MA, Rifai M, Aboelkhier MM, Elkhrashy MN, Zabady AH, Zaki MSA, Hamed EM, Dawood SA, Abuzaid Y.   +10 more
europepmc   +1 more source

Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine [PDF]

Peter Halfmann, Kathryn Loeffler, Augustine Duffy, Makoto Kuroda, Jie Yang, Elizabeth Wright, Yoshihiro Kawaoka, Ravi S. Kane   +7 more
openalex   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Methodological Issues in Taquet et al.'s analysis preclude any conclusions regarding AS01 adjuvant's specific role in dementia prevention. [PDF]

NPJ Vaccines
Williams SE, Luisi K, Liang C, Cane A, Begier E.   +4 more
europepmc   +1 more source

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

, 2008
Joseph G. Joyce, Isaac J. Krauss, Hong Chang Song, David Opalka, Karen M. Grimm, Deborah D. Nahas, Mark T. Esser, Renee Hrin, Meizhen Feng, Vadim Dudkin, Michael Chastain, John W. Shiver, Samuel J. Danishefsky   +12 more
openalex   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Vaccine selection strategies and their implications for individual versus population well-being. [PDF]

BMJ Glob Health
Bennett NG, Ferranna M, Liu X, Bloom DE.
europepmc   +1 more source

An immunogenic personal neoantigen vaccine for patients with melanoma

Nature, 2017
P. Ott, Zhuting Hu, D. Keskin, S. Shukla, Jing Sun, David j. Bozym, Wandi Zhang, Adrienne M. Luoma, A. Giobbie-Hurder, Lauren Peter, Christina Chen, Oriol Olive, T. Carter, Shuqiang Li, David J. Lieb, T. Eisenhaure, E. Gjini, Jonathan D. Stevens, W. Lane, I. Javeri, K. Nellaiappan, A. Salazar, H. Daley, Michael G. Seaman, E. Buchbinder, Charles H. Yoon, M. Harden, N. Lennon, S. Gabriel, S. Rodig, D. Barouch, J. Aster, G. Getz, K. Wucherpfennig, D. Neuberg, J. Ritz, E. Lander, E. Fritsch, N. Hacohen, Catherine J. Wu   +39 more
semanticscholar   +1 more source

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy

Advanced Science, EarlyView.
The fused EV platform AS16‐EL@MPLA/p‐FX reprograms tumor cells into cytokine‐producing factories that continuously secrete XCL1 and FLT3L to recruit and differentiate cDC1s, while embedded MPLA activates them through TLR4 signaling and AS16 prevents their exhaustion, thereby enhancing antitumor immunity and establishing durable immune memory against ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
wiley   +1 more source