Results 281 to 290 of about 886,403 (306)

Topics of Interest in Women With Myeloproliferative Neoplasms

American Journal of Hematology, EarlyView.
Women with MPN: life‐cycle phases, specific risks, and influencing factors. ABSTRACT Overview Sex and gender have emerged as central modifiers of disease biology, phenotype, and clinical outcomes in myeloproliferative neoplasms (MPNs). This review will uniquely highlight issues affecting women with MPN and articulate their relevant determinants ...
Natasha Szuber, Paola Guglielmelli, Naseema Gangat   +2 more
wiley   +1 more source

A study on the variation of cytokine and electrolyte levels in rhesus macaques, cynomolgus monkeys, and Assamese macaques

Animal Models and Experimental Medicine, EarlyView.
This study aims to investigate the variations in cytokine and electrolyte levels among rhesus macaques, cynomolgus monkeys, and assamese macaques in terms of species, sex, and age. By assessing 23 immune function indicators and 5 electrolyte indicators, significant differences in cytokine and electrolyte levels were detected across different monkey ...
Suqin Duan, Jinghan Hou, Yanyan Li, Wenting Sun, Mingxue Li, Lixiong Chen, Hongjie Xu, Weihua Jin, Quan Liu, Jie Tang, Zijun Deng, Fengmei Yang, Zhanlong He   +12 more
wiley   +1 more source

Development and validation of BCG vaccine‐induced novel granulomatous liver injury preclinical animal model

Animal Models and Experimental Medicine, EarlyView.
The study successfully developed and validated a granulomatous liver injury model using a high‐dose BCG vaccine, simulating hepatic tuberculosis and autoimmune granulomatous liver diseases. Pharmacokinetic analysis examined the metabolic behavior of first‐line antitubercular drugs (isoniazid and rifampicin) and their main metabolites under conditions ...
Swati Sharma, Abhishek Moudgil, Jyoti Grewal, Pankaj Khatri, Vishal Sharma, Madhumita Premkumar, Amanjit Bal, Dibyajyoti Banerjee, Amol N. Patil   +8 more
wiley   +1 more source

Vaccines

, 2008
Shaw, Alan R., Feinberg, Mark B.
openaire   +1 more source

Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection

Animal Models and Experimental Medicine, EarlyView.
This review explores the potential mechanisms, complications, risk factors, and future research directions related to osteoporosis secondary to SARS‐CoV‐2 infection. Key mechanisms include an imbalance between osteoclast and osteoblast activity driven by direct viral effects on bone, inflammation, hypoxia, dysregulation of noncoding RNAs, and metabolic
Jinlong Wang, Yibai Xiong, Zhiqi Song, Yanhong Li, Ling Zhang, Chuan Qin   +5 more
wiley   +1 more source

Animal models of human herpesvirus infection

Animal Models and Experimental Medicine, EarlyView.
Human herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Ziqing Jia, Dong Zhang, Lin Zhu, Jing Xue   +3 more
wiley   +1 more source

Development of a single‐nucleotide polymorphism panel genotyping system for genetic analysis of Chinese hamsters

Animal Models and Experimental Medicine, EarlyView.
Here, we developed a novel Chinese hamster genetic quality detection system using single‐nucleotide polymorphism (SNP) markers following this process. To obtain SNP loci, we conducted whole genome sequencing on 24 Chinese hamsters. Then, we employed an SNP loci screening criterion that we set up previously and initially screened 214 SNP loci with wide ...
Minghe Sun, Yafang Guo, Zhengnan Ren, Ang Song, Jing Lu, Changlong Li, Jianyi Lv, Meng Guo, Xin Liu, Xiaoyan Du, Zhaoyang Chen, Guohua Song, Yan He, Zhenwen Chen, Xueyun Huo   +14 more
wiley   +1 more source

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek   +2 more
wiley   +1 more source

High‐fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages

Angewandte Chemie International Edition, Accepted Article.
Cargo‐filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can be packaged into protein cages during their expression and self‐assembly inside cells, synthetic cargo molecules are typically incompatible with live cells and ...
Taylor Szyszka, Rezwan Siddiquee, Alex Loustau, Lachlan S. R. Adamson, Claire Rennie, Tiancheng Huang, Reginald Young, Andrew Care, Yu Heng Lau   +8 more
wiley   +1 more source

Identification of an Activity Selector for the Nitroso‐Forming Activity in Bacterial Type‐III Copper Enzymes

Angewandte Chemie International Edition, Accepted Article.
O‐aminophenol oxidases, a specialized subclass of type‐III copper proteins, play a crucial role in the biosynthesis of bioactive nitrosophenols which display antiretroviral and blood cholesterol lowering activity. Another related subclass of type‐III copper proteins, tyrosinases, closely resemble o‐aminophenol oxidases both structurally and ...
Hoa Le Xuan, Felix Panis, Annette Rompel
wiley   +1 more source