Results 21 to 30 of about 2,206,632 (403)

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

New England Journal of Medicine, 2021
Background BNT162b2 is a lipid nanoparticle–formulated, nucleoside-modified RNA vaccine encoding a prefusion-stabilized, membrane-anchored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length spike protein.
Stephen J. Thomas, E. Moreira, N. Kitchin, J. Absalon, A. Gurtman, S. Lockhart, John L. Perez, Gonzalo Pérez Marc, F. Polack, C. Zerbini, R. Bailey, K. Swanson, Xia Xu, Satrajit Roychoudhury, K. Koury, S. Bouguermouh, W. Kalina, David Cooper, R. Frenck, L. Hammitt, Ö. Türeci, H. Nell, A. Schaefer, S. Ünal, Qi Yang, P. Liberator, D. Tresnan, Susan H. Mather, P. Dormitzer, U. Şahin, W. Gruber, K. Jansen   +31 more
semanticscholar   +1 more source

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

New England Journal of Medicine, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the resulting disease, coronavirus disease 2019 (Covid-19), have spread to millions of persons worldwide.
E. Walsh, R. Frenck, A. Falsey, N. Kitchin, J. Absalon, A. Gurtman, S. Lockhart, K. Neuzil, M. Mulligan, R. Bailey, K. Swanson, Ping Li, K. Koury, W. Kalina, David Cooper, Camila R. Fontes-Garfias, P. Shi, Ö. Türeci, Kristin Tompkins, Kirsten E. Lyke, V. Raabe, P. Dormitzer, K. Jansen, U. Şahin, W. Gruber   +24 more
semanticscholar   +1 more source

Psychological characteristics associated with COVID-19 vaccine hesitancy and resistance in Ireland and the United Kingdom

Nature Communications, 2021
Identifying and understanding COVID-19 vaccine hesitancy within distinct populations may aid future public health messaging. Using nationally representative data from the general adult populations of Ireland (N = 1041) and the United Kingdom (UK; N ...
Jamie Murphy, F. Vallières, R. Bentall, M. Shevlin, O. McBride, T. Hartman, R. McKay, K. Bennett, L. Mason, J. Gibson-Miller, L. Levita, Antón P. Martínez, T. Stocks, T. Karatzias, P. Hyland   +14 more
semanticscholar   +1 more source

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

New England Journal of Medicine, 2021
Background Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 ...
S. Madhi, V. Baillie, C. Cutland, M. Voysey, A. Koen, L. Fairlie, S. Padayachee, K. Dheda, S. Barnabas, Q. Bhorat, Carmen Briner, G. Kwatra, K. Ahmed, P. Aley, Sutika Bhikha, J. Bhiman, A. Bhorat, J. du Plessis, A. Esmail, M. Groenewald, E. Horne, Shi-Hsia Hwa, A. Jose, T. Lambe, M. Laubscher, M. Malahleha, Masebole Masenya, Mduduzi S. L. Masilela, Shakeel Mckenzie, Kgaogelo Molapo, A. Moultrie, S. Oelofse, Faeezah Patel, S. Pillay, S. Rhead, H. Rodel, Lindie Rossouw, Carol Taoushanis, H. Tegally, Asha Thombrayil, Samuel van Eck, C. K. Wibmer, N. Durham, E. Kelly, T. Villafana, S. Gilbert, A. Pollard, Túlio de Oliveira, P. Moore, A. Sigal, A. Izu   +50 more
semanticscholar   +1 more source

A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults. [PDF]

, 2010
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa.
French, N, Gilks, CF, Gordon, SB, Longwe, H, Molyneux, ME, Mwafulirwa, G, Mwaiponya, M, Mwalukomo, T, White, SA, Zijlstra, EE   +9 more
core   +4 more sources

Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems [PDF]

, 2014
Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors.
Atyabi, F., Ghaemi, A., Gorji, A., Kalhor, H.R., Kelishadi, M., Moradi, A., Sajadian, A., Tabarraei, A., Tahamtan, A.   +8 more
core   +3 more sources

Ability of vaccine strain induced antibodies to neutralize field isolates of caliciviruses from Swedish cats [PDF]

, 2015
Background: Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats worldwide. Its characteristically high mutation rate leads to escape from the humoral immune response induced by natural infection and/or vaccination and ...
Berndtsson, Louise Treiberg, Hosie, Margaret, Lindhe, Anna, Samman, Ayman, Thibault, Jean-Christophe, Wensman, Jonas Johansson   +5 more
core   +2 more sources

Vaccine hesitancy: the next challenge in the fight against COVID-19

European Journal of Epidemiology, 2020
Vaccine hesitancy remains a barrier to full population inoculation against highly infectious diseases. Coincident with the rapid developments of COVID-19 vaccines globally, concerns about the safety of such a vaccine could contribute to vaccine hesitancy.
A. Dror, N. Eisenbach, S. Taiber, N. Morozov, Matti Mizrachi, Asaf Zigron, S. Srouji, E. Sela   +7 more
semanticscholar   +1 more source

Vaccine adjuvants: mechanisms and platforms

Signal Transduction and Targeted Therapy, 2023
Adjuvants are indispensable components of vaccines. Despite being widely used in vaccines, their action mechanisms are not yet clear. With a greater understanding of the mechanisms by which the innate immune response controls the antigen-specific ...
Tingmei Zhao, Yulong Cai, Yujie Jiang, Xuemei He, Yuquan Wei, Yifan Yu, Xiaohe Tian   +6 more
semanticscholar   +1 more source

Comprehensive Flow Cytometry Analysis of PEI-Based Transfections for Virus-Like Particle Production

Research, 2020
The generation of stable clones for biomolecule production is a common but lengthy and labor-intensive process. For complex molecules, such as viruses or virus-like particles (VLPs), the timeline becomes even more cumbersome. Thus, in the early stages of
Daniel J. Blackstock, Alvenne Goh, Shamitha Shetty, Giulia Fabozzi, Rong Yang, Vera B. Ivleva, Richard Schwartz, Joseph Horwitz   +7 more
doaj   +1 more source