Results 71 to 80 of about 389,573 (268)

Vaccination strategies for the prevention of meningococcal disease

Human Vaccines & Immunotherapeutics, 2018
Routine prophylactic vaccination and mass vaccination strategies have been used to control both endemic and epidemic disease caused by Neisseria meningitidis globally.
Scott Vuocolo, Paul Balmer, William C. Gruber, Kathrin U. Jansen, Annaliesa S. Anderson, John L. Perez, Laura J. York   +6 more
doaj   +1 more source

MntC-Dependent Manganese Transport Is Essential for Staphylococcus aureus Oxidative Stress Resistance and Virulence

mSphere, 2018
Staphylococcus aureus is a human pathogen that has developed several approaches to evade the immune system, including a strategy to resist oxidative killing by phagocytes.
Luke D. Handke, Alexey V. Gribenko, Yekaterina Timofeyeva, Ingrid L. Scully, Annaliesa S. Anderson   +4 more
doaj   +1 more source

The development of contraceptive vaccines [PDF]

Expert Opinion on Investigational Drugs, 2002
The use of vaccination as a means of controlling fertility was established during the last decade with the publication of a successful Phase II trial demonstrating the efficacy of this approach to family planning. However, only this one Phase II trial has been completed despite a plethora of hormonal and gamete antigens that have been proposed as ...
openaire   +3 more sources

Chiral Microneedle Arrays With Terahertz Chiroptical Activity With Chiral‐Plasmon‐Chiral‐Phonon Resonance

Advanced Materials, EarlyView.
ABSTRACT Microneedle arrays (MNAs) is a rapidly emerging technology with broad biomedical applications in drug delivery and biosensing. With sub‐millimeter dimensions and periodicity, MNAs possess geometries nearly ideal for biomedical devices operating within the terahertz (THz) spectral window.
Sang Hyun Lee, Hong Ju Jung, John Kim, Bum Chul Park, Caio V. C. R. da Silva, André F. de Moura, Nicholas A. Kotov   +6 more
wiley   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Recombinant ROP6 protein expressed in Saccharomyces cerevisiae INVSc1 cells induced strong immune response and provided significant protection against toxoplasmosis

Scientific Reports
Toxoplasma gondii is a zoonotic parasite that infects almost all warm-blooded animals and humans and results in serious health problems. There is no drug treatment for chronic toxoplasmosis.
Tuğba Karakavuk, Muhammet Karakavuk, Ceren Gül, Hüseyin Can, Aytül Gül, Sedef Erkunt Alak, Aysu Değirmenci Döşkaya, Seren Kaplan, İrem Yavuz, Hasan Akbaba, Gülşah Erel Akbaba, Didem Şen Karaman, Ahmet Efe Köseoğlu, Tolga Ovayurt, Adnan Yüksel Gürüz, Cemal Ün, Ayşe Gülten Kantarcı, Mert Döşkaya   +17 more
doaj   +1 more source

Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination

Human Vaccines & Immunotherapeutics, 2019
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is characterized by high mortality and morbidity. While IMD incidence peaks in both infants and adolescents/young adults, carriage rates are often highest in the latter age groups ...
Cynthia Burman, Lidia Serra, Charles Nuttens, Jessica Presa, Paul Balmer, Laura York   +5 more
doaj   +1 more source

Release of extracellular vesicles containing small RNAs from the eggs of Schistosoma japonicum

Parasites & Vectors, 2016
Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis. Secreted extracellular vesicles (EVs) play a key role in pathogen-host interfaces. Previous studies have shown that S. japonicum adult worms can release microRNA (
Shanli Zhu, Sai Wang, Yu Lin, Pengyue Jiang, Xiaobin Cui, Xinye Wang, Yuanbin Zhang, Weiqing Pan   +7 more
doaj   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Design and immunogenicity evaluation of pan-recombinant vaccines based on the consensus sequence of severe acute respiratory syndrome coronavirus-2 spike protein

Scientific Reports
Although multivalent vaccines are being developed to address the rapid mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), universal vaccines are needed to protect against evolving variants and seasonal epidemics.
Yoo Jin Na, Eun Bee Choi, Kwangwook Kim, Seungyeon Kim, Seo Young Moon, Yoo-kyoung Lee, Hyun Ju In   +6 more
doaj   +1 more source