Results 171 to 180 of about 159,299 (261)

COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study. [PDF]

J Infect Dis
Hofsink Q, Lissenberg-Witte BI, Haggenburg S, Goorhuis A, Hazenberg MD, Rutten CE, den Tex P, de Vries EGE, van der Veldt AAM, Kemmeren JM, de Keizer NF, Huijgens PC, Dinmohamed AG, van Roon A, Pijpers J, van Roekel C, van den Hof S, Hahné SJM, de Gier B, Heijmans J, Nijhof IS.   +20 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +2 more sources

Respiratory syncytial virus (RSV) vaccine effectiveness and antibody correlates of protection among older adults in the Community Vaccine Effectiveness (CoVE) observational study. [PDF]

EBioMedicine
Godonou ET, Callear AP, Juntila-Raymond CL, Raji D, Smith M, Rumfelt KE, Midgley CM, Feldstein LR, Jones JM, Hagen MB, Eisenberg MC, Lauring AS, Monto AS, Wagner AL, Martin ET.   +14 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

Recommendations for estimating and reporting vaccine effectiveness by time since vaccination: a COVID-19 case study. [PDF]

Am J Epidemiol
Kissling E, Nunes B, Hooiveld M, Martínez-Baz I, Monge S, Robertson C, Knol M, Sève N, Mlinarić I, Domegan L, Machado A, Whitaker H, Lazar M, Meijer A, Enkirch T, Casado I, Pérez-Gimeno G, William N, Enouf V, Kurečić Filipović S, McKenna A, Rodrigues AP, de Lusignan S, Timnea OC, Latorre-Margalef N, Castilla J, Pozo F, Hamilton M, Masse S, Ilić M, Basile L, O'Donnell J, Guiomar R, Riess M, Popescu RM, Rose AMC, Andrews N, Bacci S, Pastore Celentano L, Valenciano M, Moren A, Beutels P, Hens N, I-MOVE-COVID-19 and ECDC primary care study teams.   +43 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Mumps Virus: Replication, Immune Response, and the Changing Landscape of Vaccine Effectiveness. [PDF]

Pathogens
Risalvato J.
europepmc   +1 more source

Estimates of vaccine effectiveness against measles and mumps: 14 years follow-up of a large cohort in Wales, UK. [PDF]

Int J Epidemiol
Perry M, Gravenor MB, Cottrell S, Moore C, Griffiths LJ.   +4 more
europepmc   +1 more source