Results 81 to 90 of about 165,324 (266)
Seasonal influenza vaccine effectiveness at primary care level, Hong Kong SAR, 2017/2018 winter
Human Vaccines & Immunotherapeutics, 2019 The 2017/18 winter influenza season in Hong Kong started in early January 2018, predominated by influenza B/Yamagata. We collaborated with private medical practitioners of our sentinel surveillance system to collect respiratory specimens and clinical ...
Yung-wai Desmond Chan +3 more
doaj +1 more source
Advanced Materials, EarlyView.A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte +21 more
wiley +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
PLoS ONE, 2018 BackgroundInfluenza and pneumonia are leading causes of morbidity and mortality among the elderly. Although vaccination is a main strategy to prevent these infectious diseases, concerns remain with respect to vaccine effectiveness.MethodsDuring three ...
Joon Young Song +12 more
doaj +1 more source
Vaccination history as a confounder of studies of influenza vaccine effectiveness
Vaccine: X, 2019 Vaccination history may confound estimates of influenza vaccine effectiveness (VE) when two conditions are present: (1) Influenza vaccination is associated with vaccination history and (2) vaccination modifies the risk of natural infection in the following seasons, either due to persisting vaccination immunity or due to lower previous risk of natural ...
Ivo M. Foppa +4 more
openaire +3 more sources
Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis
Advanced Materials, EarlyView.Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne +12 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2019 Background: A field effectiveness evaluation of the influenza vaccine among children younger than five years is important due to the high burden of influenza in this age group. The epidemiology of influenza virus changes rapidly each year.
Young Kyung Kang +7 more
doaj +1 more source
Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
Advanced Materials, EarlyView.As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang +12 more
wiley +1 more source
Balkan Medical Journal, 2018 Background: Influenza has an important public health impact worldwide with its considerable annual morbidity among persons with or without risk factors and its serious complications among persons in high-risk groups.
Can Hüseyin Hekimoğlu1 +5 more
doaj +1 more source