Results 191 to 200 of about 2,076,500 (256)

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

From Crisis to Control: A Study of Typhoid Conjugate Vaccine Efficacy in Harare, Zimbabwe (2017-2024). [PDF]

Open Forum Infect Dis
Bvochora T, Manyara J, Thilliez G, Vere M, Mukeredzi I, Nhamo D, Chitiyo F, Muzondo A, Juru A, Chonzi P, Phiri I, Smith AM, Chaibva BV, Mapingure M, Fuller W, Shrestha P, Nair P, Kingsley RA, Laxminarayan R, Musuka G, Mashe T.   +20 more
europepmc   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Long-term antigen reduction does not achieve durable HBV control in mice but enhances therapeutic vaccine efficacy. [PDF]

JHEP Rep
Michler T, Kosinska A, Merdan O, Hagen P, Bunse T, Öz EA, Su J, Busch DH, Mogler C, Protzer U.   +9 more
europepmc   +1 more source

Current evidence and insights on single vs. double dose of basiliximab in adult solid organ transplant recipients: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this systematic review was to assess all available clinical data regarding the use of a single dose of basiliximab in solid organ transplantation compared to the standard double dosage, with particular interest in efficacy, safety and cost‐savings.
Alessio Provenzani, Braidon A. Lape, Anneliese M. Harp, Victoria Weisbrod, Lavinia Piazza   +4 more
wiley   +1 more source

Association between COVID-19 vaccine efficacy and epidemic force of infection. [PDF]

NPJ Vaccines
Xu J, Halloran ME, Moore M, Zhang L, Hyrien O, Luedtke A, El Sahly HM, Baden LR, Goepfert PA, Gray G, Grinsztejn B, Sobieszczyk ME, Falsey AR, Robinson ST, Garcia NMG, Zhou H, van Dromme I, Truyers C, Hirsch I, Neuzil KM, Corey L, Kublin JG, Follmann D, Janes HE, Gilbert PB, Huang Y.   +25 more
europepmc   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Simulation of synthetic health records for assessment of causal inference methods for vaccine efficacy

Velasco-Pardo V, Daines L, Katikireddi SV, Ritchie L, Robertson□ C, Simpson CR, McCowan C, Swallow B.   +7 more
europepmc   +1 more source

Molecular Variation in Porcine Circovirus Type 2 in Jalisco, Mexico, and Its Potential Impact on Vaccine Efficacy. [PDF]

Vaccines (Basel)
Galindo-Barboza AJ, Rivera-Benítez JF, De la Luz-Armendáriz J, Sánchez-Betancourt JI, Hernández J, Burgara-Estrella AJ, Sauceda-Cerecer SG, Márquez-Valdelamar L, Alba-Campos JE.   +8 more
europepmc   +1 more source