Results 81 to 90 of about 2,248,189 (298)

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Meeting of the Global Advisory Committee on Vaccine Safety 7-8 June 2017

, 2017
The Global Advisory Committee on Vaccine Safety (GACVS), an independent expert clinical and scientific advisory body, provides WHO with scientifically rigorous advice on vaccine safety issues of potential global importance.1 GACVS held its 36th meeting ...
The Global Advisory Committee on Vaccine Safety
core  

An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Haemophilus influenzae type b vaccine [PDF]

, 2013
BACKGROUND: In two clinical trials, low-grade fever was observed more frequently after coadministration than after separate administration of two recommended routine pediatric vaccines.
Rose, Markus A., William C Gruber, Sherryl Baker, Christine Juergens, Beate Schmoele-Thoma, Gruber, William C., Stefan Zielen, Zielen, Stefan, Jürgens, Christine, Schmoele-Thoma, Beate, Baker, Sherryl, Markus A Rose   +11 more
core   +2 more sources

Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

Frontiers in Immunology
IntroductionRotavirus remains a major cause of mortality among young children worldwide, underscoring the urgent need for new vaccines. The present study evaluated the repeated-dose toxicity and immunogenicity of a bivalent rotavirus subunit candidate ...
Wei Pan, Wei Pan, Yingjie Cheng, Yingjie Cheng, Xiaojing Shi, Xiaojing Shi, Yunxiang Chen, Yunxiang Chen, Yunxiang Chen, Cong Xu, Cong Xu, Zhengbiao Yang, Zhengbiao Yang, Qijiong Lu, Qijiong Lu, Qijiong Lu, Lei Wen, Lei Wen, Lei Wen, Fang Liu, Fang Liu, Tingli Bian, Tingli Bian, Li Qin, Li Qin, Shuizhen Pan, Shuizhen Pan, Ying Chen, Ying Chen, Changwei Wu, Changwei Wu, Lijiang Zhang, Lijiang Zhang, Lijiang Zhang, Hongzhong Yang, Hongzhong Yang, Hongzhong Yang   +36 more
doaj   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants

, 1999
Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988 and recently, licensure of the vaccine in Korea has been sought.
박민수
core   +1 more source

Evidence of blood stage efficacy with a virosomal malaria vaccine in a Phase IIa clinical trial [PDF]

, 2008
Background Previous research indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine.
Zurbriggen, R, Gerd Pluschke, Sarah C. Gilbert, Hill, Adrian, Hutchings, Claire, Gilbert Sarah C., Sinden, Robert, Gilbert, Sarah, Pluschke, G, Gilbert, Sarah C., Zurbriggen Rinaldo, Vogel, Denise, Jack L. Williams, Correa, S, Andrews Laura, Okitsu, SL, Westerfeld Nicole, Andrews, Laura, Vogel, D, David W. Porter, Thompson, Fiona, Okitsu, Shinji, Ian Poulton, Todryk, S, Shinji L. Okitsu, Denise Vogel, Dunachie Susanna, Thompson Fiona M., Berthoud, Tamara, Andrews, L, Sinden, R, Porter David W., Pluschke, Gerd, Sarah C Gilbert, Sinden Robert, Poulton Ian, Fiona M Thompson, Berthoud, T, Zurbriggen, Rinaldo, Rinaldo Zurbriggen, Susanna Dunachie, Westerfeld, Nicole, Tamara Berthoud, Todryk, Stephen, Okitsu Shinji L., Hill Adrian V. S., Correa Simon, Berthoud Tamara, Dunachie, S, Westerfeld, N, David W Porter, Nicole Westerfeld, Todryk Stephen, Porter, David, Correa, Simon, Thompson, FM, Pluschke Gerd, Hutchings, C, Poulton, Ian, Hutchings Claire, Williams, JL, Vogel Denise, Shinji L Okitsu, Fiona M. Thompson, Poulton, I, Jack L Williams, Simon Correa, Laura Andrews, Dunachie, Susanna, Adrian V S Hill, Robert Sinden, Porter, DW, Stephen Todryk, Williams, Jack, Claire Hutchings, Williams Jack L.   +75 more
core   +1 more source

Collaboration within the global vaccine safety surveillance ecosystem during the COVID-19 pandemic: lessons learnt and key recommendations from the COVAX Vaccine Safety Working Group

BMJ Global Health
This analysis describes the successes, challenges and opportunities to improve global vaccine safety surveillance as observed by the Vaccine Safety Working Group from its role as a platform of exchange for stakeholders responsible for monitoring the ...
Rebecca E Chandler, James Milligan, Emmanuelle Espie, Katharina Hartmann, Madhava Ram Balakrishnan, Daniel Brasseur, Philip Bryan, Corinne Jouquelet-Royer, Linda Nesbitt, Shanthi Pal, Alexander Precioso, Paulo Takey, Robert T Chen   +12 more
doaj   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source