Results 71 to 80 of about 183,149 (258)

Communicating COVID-19 Vaccine Safety: Knowledge and Attitude Among Residents of South East, Nigeria

Infection and Drug Resistance, 2021
Luke Ifeanyi Anorue, Alphonsus Chukwuma Ugwu, Stanley Uzoamaka Ugboaja, Uzoma O Nwabunze, Chinyere Christiana Ugwulor-Onyinyechi, Chioma Njoku Department of Mass Communication, University of Nigeria, Nsukka, NigeriaCorrespondence: Chioma NjokuDepartment ...
Anorue LI, Ugwu AC, Ugboaja SU, Nwabunze UO, Ugwulor-Onyinyechi CC, Njoku C   +5 more
doaj  

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Vaccine Safety International Monitoring

Безопасность и риск фармакотерапии, 2019
Vaccine safety is an important aspect of mass immunization of the population. Adverse reactions that occur following vaccination result in a decrease in public confidence. The aim of this research was to identify information on the development of adverse
M. A. Darmostukova, I. I. Snegireva, N. Yu. Velts, A. S. Kazakov, R. N. Alyautdin   +4 more
doaj   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Editorial: Immunological aspects of vaccine safety

Frontiers in Immunology, 2023
Michael Vajdy, Barbara A. Rath, Kawsar R. Talaat   +2 more
doaj   +1 more source

Strategies for identifying and using diverse global health data: perspectives from data searching and meta-analyses on antimicrobial resistance

Discover Public Health
Searching for and utilizing biomedical data is an essential part of most research efforts, including in public health, and almost always involves use of major online databases.
Danielle M. Venne, David M. Hartley, C. Scott Dorris, Laura M. Torres, Marissa D. Malchione, Elizabeth A. Mitgang, Jesse L. Goodman   +6 more
doaj   +1 more source

First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models

Pathogens
Caseous lymphadenitis (CLA) is a chronic and subclinical bacterial disease of ruminants caused by Corynebacterium pseudotuberculosis (C. pseudotuberculosis) infection.
Gyeong-Seo Park, Somin Lee, Min A Jeong, So Young Lee, Dong-Geun Cho, WonIl Cho, Seung-Chai Kim, Hwan-Ju Kim, Taek Geun Lee, Chang-Gi Jeong, Won-Il Kim, Yeonsu Oh, Ho-Seong Cho, Byoung-Joo Seo, Chonghan Kim   +14 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source