Results 61 to 70 of about 190,239 (217)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Communicating COVID-19 Vaccine Safety: Knowledge and Attitude Among Residents of South East, Nigeria

Infection and Drug Resistance, 2021
Luke Ifeanyi Anorue, Alphonsus Chukwuma Ugwu, Stanley Uzoamaka Ugboaja, Uzoma O Nwabunze, Chinyere Christiana Ugwulor-Onyinyechi, Chioma Njoku Department of Mass Communication, University of Nigeria, Nsukka, NigeriaCorrespondence: Chioma NjokuDepartment ...
Anorue LI, Ugwu AC, Ugboaja SU, Nwabunze UO, Ugwulor-Onyinyechi CC, Njoku C   +5 more
doaj  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models

Pathogens
Caseous lymphadenitis (CLA) is a chronic and subclinical bacterial disease of ruminants caused by Corynebacterium pseudotuberculosis (C. pseudotuberculosis) infection.
Gyeong-Seo Park, Somin Lee, Min A Jeong, So Young Lee, Dong-Geun Cho, WonIl Cho, Seung-Chai Kim, Hwan-Ju Kim, Taek Geun Lee, Chang-Gi Jeong, Won-Il Kim, Yeonsu Oh, Ho-Seong Cho, Byoung-Joo Seo, Chonghan Kim   +14 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Vaccine Safety International Monitoring

Безопасность и риск фармакотерапии, 2019
Vaccine safety is an important aspect of mass immunization of the population. Adverse reactions that occur following vaccination result in a decrease in public confidence. The aim of this research was to identify information on the development of adverse
M. A. Darmostukova, I. I. Snegireva, N. Yu. Velts, A. S. Kazakov, R. N. Alyautdin   +4 more
doaj   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Editorial: Immunological aspects of vaccine safety

Frontiers in Immunology, 2023
Michael Vajdy, Barbara A. Rath, Kawsar R. Talaat   +2 more
doaj   +1 more source

Strategies for identifying and using diverse global health data: perspectives from data searching and meta-analyses on antimicrobial resistance

Discover Public Health
Searching for and utilizing biomedical data is an essential part of most research efforts, including in public health, and almost always involves use of major online databases.
Danielle M. Venne, David M. Hartley, C. Scott Dorris, Laura M. Torres, Marissa D. Malchione, Elizabeth A. Mitgang, Jesse L. Goodman   +6 more
doaj   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source