Results 71 to 80 of about 2,733,451 (251)
Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT
Immunotherapy has shed light on clinical oncology for several decades.Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng +11 morewiley +1 more sourceIntrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong +10 morewiley +1 more sourceInjection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response
Frontiers in Molecular Neuroscience, 2019 Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated Tingfu Du, Tingfu Du, Tingfu Du, Zhengcun Wu, Zhengcun Wu, Haiyu Luo, Haiyu Luo, Shuaiyao Lu, Shuaiyao Lu, Kaili Ma, Kaili Ma, Kaili Ma +11 moredoaj +1 more sourceA randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children. [PDF]
, 2010 BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages.Schultsz, C, To, S.D., Vinh Chau Nguyen Van, Dolecek, C., Thi Diem Ha Tran, Dolecek, Christiane, Nguyen, V.M.H., Van Vinh Chau Nguyen, Upton Anthony, Nguyen, T.D., Thi Dung Nguyen, James P May, Marques, F, Nguyen, T.T., Schultsz, Constance, Glover, Clare, Upton, A., Nguyen, Thi Cam Binh, Stockwell, E, Hoang Nguyen Van Minh, Schultsz, C., Farrar, Jeremy, Upton, A, Glover, C., Van Minh Hoang Nguyen, Nguyen, Thanh Truong, Filipe Marques, Nguyen, TCB, James P. May, Pham Van Toi, James I. Campbell, Stockwell, E., Pham, Van Toi, Elaine Stockwell, Nga Tran Thi Thu, Ninh, TTV, Tran, T.D.H., May, James P, James I Campbell, To, Song Diep, Nguyen, T.C.B., Toi Pham Van, Tran, Thi Thu Nga, May, J.P., Tran, TTN, Budhram, R., Tran, T.T.N., Simmons, Cameron P, Van Toi Pham, Tran, N.B.C., Lam, W., Glover Clare, Campbell, J.I., Marques, F., Ha Tran Thi Diem, Bich Chau Tran Nguyen, Tran, TDH, Nguyen, VVC, Campbell, JI, Ninh Thi Thanh Van, To, SD, Schultsz Constance, Dougan, Gordon, Lam, Winnie, Nguyen, V.V.C., Campbell James I., Farrar Jeremy, Dolecek, C, Upton, Anthony, Christiane Dolecek, Cameron P. Simmons, Stockwell, Elaine, Tran, Tinh Hien, Ninh, Thi Thanh Van, Nguyen Thi Cam Binh, Budhram, Ronald, Nguyen Thi Dung, Dung Nguyen Thi, Hien Tran Tinh, Cao, Thu Thuy, Van Ninh Thi Thanh, Cao, T.T., Constance Schultsz, Tran, NBC, Tran Tinh Hien, Stockwell Elaine, Nguyen, Van Minh Hoang, Dolecek Christiane, Tran, TH, Lam Winnie, Campbell, James I, Nguyen, Van Vinh Chau, Tran Thi Diem Ha, Nguyen, Thi Dung, Winnie Lam, Gordon Dougan, May James P., Farrar, J, Nguyen Bich Chau Tran, Nguyen, TD, Jeremy Farrar, Cao Thu Thuy, Tinh Hien Tran, Thi Thanh Van Ninh, Budhram, R, Pham, V.T., Thu Thuy Cao, Simmons, C.P., Nguyen, TT, Glover, C, Thuy Cao Thu, Simmons, CP, Dougan, G., Ronald Budhram, Pham, V.M., Thi Cam Binh Nguyen, Pham, Van Minh, Lam, W, Thanh Truong Nguyen, Nguyen Van Minh Hoang, Farrar, J., Van Minh Pham, Tran, Nguyen Bich Chau, Thi Thu Nga Tran, Song Diep To, Nguyen Thanh Truong, Dougan Gordon, Pham Van Minh, Cao, TT, Clare Glover, Nguyen Van Vinh Chau, To Song Diep, Ninh, T.T.V., Nguyen, MV, Budhram Ronald, Tran Nguyen Bich Chau, Marques, Filipe, Tran, Thi Diem Ha, Simmons Cameron P., Binh Nguyen Thi Cam, Tran, T.H., Cameron P Simmons, Pham, VM, Tran Thi Thu Nga, Marques Filipe, Pham, VT, Minh Pham Van, May, JP, Dougan, G, Anthony Upton, Truong Nguyen Thanh +150 morecore +1 more sourceAn Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines
Advanced Science, EarlyView.Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo +18 morewiley +1 more sourceRepeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys
Frontiers in ImmunologyIntroductionRotavirus remains a major cause of mortality among young children worldwide, underscoring the urgent need for new vaccines. The present study evaluated the repeated-dose toxicity and immunogenicity of a bivalent rotavirus subunit candidate ...Wei Pan, Wei Pan, Yingjie Cheng, Yingjie Cheng, Xiaojing Shi, Xiaojing Shi, Yunxiang Chen, Yunxiang Chen, Yunxiang Chen, Cong Xu, Cong Xu, Zhengbiao Yang, Zhengbiao Yang, Qijiong Lu, Qijiong Lu, Qijiong Lu, Lei Wen, Lei Wen, Lei Wen, Fang Liu, Fang Liu, Tingli Bian, Tingli Bian, Li Qin, Li Qin, Shuizhen Pan, Shuizhen Pan, Ying Chen, Ying Chen, Changwei Wu, Changwei Wu, Lijiang Zhang, Lijiang Zhang, Lijiang Zhang, Hongzhong Yang, Hongzhong Yang, Hongzhong Yang +36 moredoaj +1 more sourceA Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine
, 2013 [[abstract]]AbstractBackground Large-scale outbreaks of enterovirus 71 (EV71) infections have occurred in Asia-Pacific regions. Severe complications include encephalitis and poliomyelitis-like paralysis, cardiopulmonary collapse, and death, necessitating Cheng, A;Fung, CP;Liu, CC;Lin, YT;Tsai, HY;Chang, SC;Chou, AH;Chang, JY;Jiang, RH;Hsieh, YC;Su, IJ;Chong, PCS;Hsieh, SMcore +1 more sourceDual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo +12 morewiley +1 more sourceSafety of the recombinant cholera toxin B subunit, killed whole-cell (rBS-WC) oral cholera vaccine in pregnancy [PDF]
, 2012 INTRODUCTION: Mass vaccinations are a main strategy in the deployment of oral cholera vaccines. Campaigns avoid giving vaccine to pregnant women because of the absence of safety data of the killed whole-cell oral cholera (rBS-WC) vaccine.Jin Kyung Park (78612), Jacqueline L. Deen (148731), Mohammad Ali, Abdul A. Saleh, Saleh, A. A., Na Yoon Chang (148714), Rita Reyburn (130140), Stephen Obaro (148749), Sunheang Shin (148734), Anna Lena Lopez, Sack, D., Kamala Thriemer, Said M. Ali, Ramadhan Hashim (148699), Ahmed M. Khatib (130136), David Sack, Lorenz von Seidlein, Anna Lena Lopez (92298), Aguado, M. T., Raymond Hutubessy (130149), Godwin Enwere, Shaame, A. J., Ahmed M. Khatib, Maria Teresa Aguado (148740), Godwin Enwere (148705), Abdul A. Saleh (148759), Attiye J Shaame, Raymond Hutubessy, John D. Clemens, Park, J. K., Jacqueline L. Deen, Sunheang Shin, Said M Ali, Abdul A Saleh, Attiye J. Shaame, Mohammad Ali (73095), Jiddawi, M. S., Maria Teresa Aguado, Na Yoon Chang, Rita Reyburn, Lena Lopez, Schaetti, C., John D. Clemens (148728), Attiye J. Shaame (148753), Marie Paule Kieny, Khatib, A. M., Reyburn, R., Ley, B., Shin, S., Lopez, A. L., Mohamed S. Jiddawi (148765), Deok Ryun Kim, Stephen Obaro, Thriemer, K., Ahmed M Khatib, Jacqueline L Deen, Clemens, J. D., Kieny, M. P., Mohamed S Jiddawi, Ali, S. M., Hashim, R., John D Clemens, David Sack (148746), Enwere, G., Chang, N. Y., Deok Ryun Kim (78610), Ramadhan Hashim, Benedikt Ley, Mohamed S. Jiddawi, Ali, M., Deen, J. L., Benedikt Ley (148722), von Seidlein, L., Hutubessy, R., Christian Schaetti (130127), Kim, D. R., Christian Schaetti, Lorenz von Seidlein (45473), Kamala Thriemer (148725), Obaro, S., Marie Paule Kieny (148743), Said M. Ali (130132), Jin Kyung Park, Shin, Sunheang, Ali, Mohammad, Aguado, Maria Teresa, von Seidlein, Lorenz, Park, Jin Kyung, Hashim, Ramadhan, Khatib, Ahmed M., Jiddawi, Mohamed S., Hutubessy, Raymond, Lopez, Anna Lena, Obaro, Stephen, Kim, Deok Ryun, Shaame, Attiye J., Clemens, John D., Deen, Jacqueline L., Kieny, Marie Paule, Schaetti, Christian, Reyburn, Rita, Enwere, Godwin, Chang, Na Yoon, Saleh, Abdul A., Ley, Benedikt, Sack, David, Thriemer, Kamala, Ali, Said M. +107 morecore +2 more sources
