Results 211 to 220 of about 1,398,780 (286)

Intratumoural tigilanol tiglate in the multicentre treatment of equine sarcoids and cutaneous melanomas

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Intralesional chemotherapeutic administration represents an important treatment option for equine cutaneous neoplasia. Tigilanol‐tiglate (TT), a novel molecule extracted from Fontainea picrosperma, an Australian rainforest plant, is registered for intratumoural treatment of canine MCT, leading to rapid oncosis and tumour slough ...
Raphael Labens   +15 more
wiley   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

open access: yesThe FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi   +16 more
wiley   +1 more source

Canine papillomavirus: status of diagnostic methods and vaccine innovations. [PDF]

open access: yesVirol J
Feng Y   +11 more
europepmc   +1 more source

Short coiled‐coil proteins from plants and metazoans – the ‘jacks of all trades’

open access: yesThe FEBS Journal, EarlyView.
Short coiled‐coil proteins from plants and metazoans—true ‘jacks of all trades’—play supporting but crucial roles in cellular stress response, metabolism, autophagy, and membrane dynamics. Despite their small size and modest sequence conservation, proteins like plant LSUs and metazoan SCOCs showcase remarkable functional versatility shaped by evolution,
Agnieszka Sirko   +2 more
wiley   +1 more source

The whole genome analysis of the wild-type and attenuated orf virus reveals that ORF022 facilitates viral replication. [PDF]

open access: yesBMC Genomics
Jing T   +9 more
europepmc   +1 more source

Evaluation of the effect of an extract of Sphingomonas xenophaga present in a Thermal Spring Water in the management of sensitive skin associated with cutaneous vascular disorder

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Inhibition of the kallikrein‐kinin system is a potential approach to the dermocosmetic treatment of skin disorders associated with redness. We showed that a cream formulation with a Sphingomonas ferment extract inhibiting this system was effective in improving vascular disorder after repeated application in female volunteers with sensitive and reactive
Pascal Hilaire   +7 more
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

open access: yesImmunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder   +4 more
wiley   +1 more source

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