Results 111 to 120 of about 308,174 (247)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection

Frontiers in Immunology
IntroductionThe 4CMenB vaccine licensed against serogroup B Neisseria meningitidis (MenB) contains three recombinant proteins and Outer Membrane Vesicles (OMV) from a New Zealand epidemic strain. The protective response mediated on differentmeningococcal
Giacomo Vezzani, Giacomo Vezzani, Viola Viviani, Martina Audagnotto, Alessandro Rossi, Paolo Cinelli, Nicola Pacchiani, Chiara Limongi, Laura Santini, Fabiola Giusti, Sara Tomei, Giulia Torricelli, Elisa Faenzi, Chiara Sammicheli, Simona Tavarini, Adriana Efron, Alessia Biolchi, Oretta Finco, Isabel Delany, Elisabetta Frigimelica   +19 more
doaj   +1 more source

Malaria Vaccines: Current Achievements and Path Forward

Malaria remains a significant global health challenge. Although the recent approval of the liver-stage vaccines RTS, S and R21 marks significant progress in malaria control, challenges remain in achieving long-lasting and broad protection. In this review,
Jiayan Chen, Xiaomeng He, Bei Yang, Qi Wang   +3 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer

Nature Communications
The prefusion conformation of human metapneumovirus fusion protein (hMPV Pre-F) is critical for eliciting the most potent neutralizing antibodies and is the preferred immunogen for an efficacious vaccine against hMPV respiratory infections.
Mark J. G. Bakkers, Tina Ritschel, Machteld Tiemessen, Jacobus Dijkman, Angelo A. Zuffianò, Xiaodi Yu, Daan van Overveld, Lam Le, Richard Voorzaat, Marlies M. van Haaren, Martijn de Man, Sem Tamara, Leslie van der Fits, Roland Zahn, Jarek Juraszek, Johannes P. M. Langedijk   +15 more
doaj   +1 more source

Inverse vaccines - Friend, Not Foe: How Inverse Vaccines Tackle Autoimmune Diseases [PDF]

Inverse vaccines are a new and exciting approach to treating autoimmune diseases. Unlike traditional vaccines that train the immune system to fight off pathogens, inverse vaccines aim to reprogram the immune system to stop attacking healthy ...
Qiongqiong Angela, Zhou, Rumiana, Tenchov   +1 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Proportion of Patients in the United States Who Fill Their Nirmatrelvir/Ritonavir Prescriptions

Infectious Diseases and Therapy
Introduction Although real-world studies demonstrate that those prescribed nirmatrelvir/ritonavir (and particularly within 5 days of symptom onset) are less likely to experience severe COVID-19 outcomes, prior studies show that only a small fraction of ...
Abby E. Rudolph, Farid L. Khan, Tanya G. Singh, Srinivas Rao Valluri, Laura A. Puzniak, John M. McLaughlin   +5 more
doaj   +1 more source

To Vaccinate or Not to Vaccinate [PDF]

Infectious Diseases in Obstetrics and Gynecology, 1994
openaire   +2 more sources

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source